Heat-and-freeze therapy plus immunotherapy aims to turn liver tumors into cancer-fighting vaccines
NCT ID NCT06889610
First seen Nov 21, 2025 · Last updated Jun 17, 2026 · Updated 25 times
Summary
This study tests a two-step approach for people with liver metastases from triple-negative breast cancer, melanoma, or colorectal cancer. First, doctors use heat or cold to destroy some liver tumors, which may release cancer signals that train the immune system. Then, patients receive an immunotherapy drug (pucotenlimab) to boost the attack on remaining tumors. The goal is to shrink or control the cancer, not to cure it, and participants must have at least three liver tumors and be well enough for daily activities.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Phone: •••-•••-•••• Email: •••••@•••••
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Locations
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Fudan University Shanghai Cancer Center
RECRUITINGShanghai, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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