Fudan University

This study tests new drug combinations (ADC drugs with or without HRS-4642 or immunotherapy) in 160 people with advanced pancreatic cancer that cannot be removed by surgery or has spread. The goal is to find the safest and most effective doses to shrink tumors and control the dis…

This study tests a new drug (QL1706) combined with standard chemotherapy, with or without another drug (bevacizumab), as a first treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if the combination shrinks tumors or control…

This study tests whether adding immunotherapy to a special type of radiation (that spares tumor-draining lymph nodes) plus chemotherapy can help adults with advanced esophageal cancer live longer without the disease getting worse. About 432 participants will receive either the tr…

This study tests two different treatment plans for people with locally advanced rectal cancer that hasn't spread. One group gets standard long-course chemoradiation followed by chemo. The other gets short-course radiation followed by chemo, an immunotherapy drug (PD-1 antibody), …

This study looks at different drug combinations for people with advanced stomach or gastroesophageal junction cancer that has not responded to first treatment. It involves 250 adults aged 18-80 whose cancer has spread or cannot be removed. The goal is to see how well these second…

This study tests two different radiation schedules (long vs short) combined with chemotherapy and immunotherapy in people with a specific type of locally advanced rectal cancer (MSS type). The goal is to see which approach leads to more complete tumor disappearance and helps more…

This study tests whether giving radiation only to the specific neck areas where cancer has spread is as effective as treating the whole upper neck. It includes 462 adults with nasopharyngeal cancer that hasn't spread elsewhere. The goal is to reduce side effects like thyroid or t…

This study tests whether adding a liver-directed chemotherapy infusion (HAIC) to a combination of two drugs (sintilimab and bevacizumab) can help people with advanced liver cancer live longer without their disease getting worse. The study will include 164 adults with liver cancer…

This study looks at whether giving radiation therapy after surgery can help prevent thyroid cancer from coming back in people with a high risk of recurrence. About 80 adults with certain types of thyroid cancer will receive adjuvant radiotherapy and be followed for several years.…

This study tests a new approach for people with advanced breast, melanoma, or colorectal cancer that has spread to the liver. Doctors will use a special heat-based procedure to destroy some liver tumors, which may activate the immune system like a vaccine. Then, they add immunoth…

This study tests whether adding the drug cadonilimab (AK104) and radiotherapy to standard chemotherapy improves outcomes for people with a common type of colorectal cancer that has spread to the liver. About 73 participants will be randomly assigned to receive either the new comb…

This study tests whether a transplant of donated umbilical cord blood can help control Epstein-Barr virus (EBV)-related lymphoproliferative diseases, including chronic active EBV infection and EBV-associated lymphoma. About 80 people aged 14 to 80 will receive the transplant and …

This study tests whether giving another round of antibody-drug conjugates (ADCs) is safe and works for people with advanced breast cancer who have already tried this type of treatment. About 160 adults with breast cancer that has spread will receive the same or a different ADC. T…

This study tests whether a less extensive neck surgery (selective neck dissection) is as safe and effective as the standard more extensive surgery (modified neck dissection) for people with papillary thyroid cancer that has spread to only 1-2 small lymph nodes in the side of the …

This study tests personalized treatments for young women (ages 18-45) with endometrial cancer who want to preserve their fertility. Researchers use the tumor's genetic profile to assign the best therapy—hormones or immunotherapy—to improve the chance of complete cancer disappeara…

This study tests whether a new drug (serplulimab) combined with chemotherapy works better than another drug (nivolumab) combined with chemotherapy before surgery for stage II to IIIa squamous non-small cell lung cancer. About 116 adults aged 18 to 75 who can tolerate surgery will…

This study tests an oral drug called tunlametinib in people with advanced melanoma that has a specific NRAS gene mutation and has stopped responding to standard immunotherapy. About 110 adults will take the drug to see if it shrinks tumors and how safe it is. The goal is to offer…

This study tests a new combination of three drugs—chemotherapy (GEMOX), a targeted therapy (Donafenib), and an immunotherapy (Tislelizumab)—in people with advanced biliary tract cancer that cannot be removed by surgery. The goal is to see if this mix shrinks tumors and improves s…

This study looks at whether giving radiation therapy after completely removing a thymoma (a rare chest tumor) can help people with stage II or III disease live longer without the cancer coming back. About 238 adults aged 18-75 who had surgery within the last 3 months will be rand…

This study is testing a new blood test that looks at tiny pieces of DNA floating in the blood to find pancreatic neuroendocrine tumors early and tell them apart from other pancreatic tumors. Researchers will study 1,000 adults with certain pancreatic tumors who haven't had treatm…

This study tests a skin protectant called Pinoxin to see if it can prevent skin injuries caused by radiation therapy in cancer patients. About 202 adults with cancer who are starting radiation will be randomly assigned to use either Pinoxin or a placebo cream. The main goal is to…

This study tests whether limiting eating to a 10-hour window each day can lower the chance of developing gestational diabetes in pregnant women at high risk. Researchers will compare this approach to usual eating habits over 3 months in 240 participants. The goal is to see if thi…

This study is looking at whether a blood test that detects tumor DNA (ctDNA) can help doctors monitor how well stomach cancer treatment is working. About 600 adults with stomach cancer will give blood samples before and during treatment. The goal is to see if changes in ctDNA lev…

This study looks at how the pain medicine remifentanil behaves in low-weight intensive care patients who need a breathing machine. Researchers will measure drug levels in the blood and check blood pressure changes. The goal is to find the right dose for safer and more effective s…

This study aims to find out which types of HPV are most common in anal cancer patients in China and how the disease affects people. Researchers will collect samples and medical information from 300 patients across multiple hospitals. The goal is to better understand the virus's r…

This study will follow 3000 people in China with peripheral T-cell lymphoma, a rare blood cancer, to learn how the disease behaves and how it is currently treated. Researchers will collect medical records and test samples to understand what treatments work best and why some patie…

This study looks at whether special PET scans can predict if a targeted drug (anti-TROP2 ADC) will work for people with advanced HER2-negative breast cancer. About 45 participants will get two types of PET scans before starting treatment. The goal is to see if scan results can he…

This study is testing whether a blood test that looks for tiny bits of tumor DNA can find colorectal cancer recurrence earlier than standard methods like CT scans and CEA blood tests. About 584 people who had surgery for stage I-III colorectal cancer will be randomly assigned to …

This study aims to understand why some lung cancers with a specific genetic change (ROS1 fusion) stop responding to the drug entrectinib. Researchers will analyze tumor or blood samples from 38 people who have already taken entrectinib as part of their regular care. The goal is t…

This study looks at whether the bacteria in your gut can help predict how well a combination of immunotherapy and chemotherapy works for advanced stomach cancer. About 300 adults with metastatic or locally advanced stomach cancer who haven't had chemo or immunotherapy before will…

This study looks at how different types of anesthesia affect cancer cells and recovery in people having surgery for colorectal cancer. Ninety adults will be randomly assigned to receive opioid-free, opioid-sparing, or standard opioid-based anesthesia. Researchers will measure blo…