Blood test may help personalize breast cancer therapy
NCT ID NCT07394218
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a blood test that tracks tumor DNA (ctDNA) can help doctors decide when to intensify treatment for HER2-negative metastatic breast cancer. All 122 participants start with antibody-drug conjugate (ADC) therapy. After two cycles, those whose disease hasn't worsened are split into groups based on how much their ctDNA levels dropped, with some getting additional immunotherapy. The goal is to see if this personalized approach improves outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Antibody-drug conjugate (ADC) therapy (sacituzumab govitecan or trastuzumab deruxtecan) with or without ivonescimab
- What this could lead to
- If successful, this could show that monitoring ctDNA levels helps doctors personalize treatment, potentially improving outcomes for people with metastatic breast cancer.
- What could go wrong
- This is a small, early-phase study (122 people) focused on a biomarker, not a direct treatment comparison. The approach may not improve survival or could add side effects from extra therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fudan University Shanghai Cancer Center
RECRUITINGShanghai, Shanghai Municipality, 200032, China
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