Fudan University

This study tests whether adding surgery and targeted radiation to a new hormone drug (rezvilutamide) can help men whose prostate cancer has spread to a few spots (oligometastatic). About 300 men will be split into three groups: one gets the drug alone, another gets the drug plus …

This study looks at whether the drug hetrombopag can help prevent low platelet counts (thrombocytopenia) caused by chemotherapy in breast cancer patients who are at high risk for this side effect. About 126 participants will be split into three groups: one getting no preventive d…

This study tests whether adding two experimental drugs (iparomlimab and tovorilimab) to standard chemotherapy and bevacizumab can shrink tumors in people with advanced mesothelioma who have not had prior treatment. About 37 adults aged 18-75 with confirmed advanced mesothelioma w…

This study tests whether adding the drug disitamab vedotin to standard BCG therapy can help keep high-risk, early-stage bladder cancer from returning. It includes 182 adults whose cancer has been surgically removed but is at high risk of coming back. Participants will receive eit…

This study looks at whether giving a drug called leucogen along with the cancer pill pralsetinib can prevent low white blood cell counts in people with RET fusion-positive non-small cell lung cancer. About 25 people who have not had prior treatment will take part. The main goal i…

This study tests a treatment called multimodal thermal therapy (MTT) that uses both freezing and heating to destroy liver tumors. The goal is to see if this approach can control the cancer and also trigger the body's immune system to fight it. About 120 adults with liver cancer o…

This study tests three ways of giving the immunotherapy drug toripalimab to people with early-stage lung cancer that can be removed by surgery. The goal is to see which timing works best: before surgery only, after surgery only, or both before and after. About 759 adults with sta…

This study tests two drugs together—pucotenlimab and becotatug vedotin—for people with advanced cutaneous squamous cell carcinoma that cannot be removed by surgery. The goal is to see if the combination shrinks tumors better than current treatments. About 38 participants will rec…

This study tests a new treatment for people with high-risk locally advanced rectal cancer. It combines a shorter course of radiation with chemotherapy and an immunotherapy drug (serplulimab). The goal is to see if this approach leads to more tumors completely disappearing compare…

This study tests whether a single, low dose of radiation to all visible tumors can help immunotherapy work again in people with advanced esophageal cancer that stopped responding to standard treatment. About 32 adults will receive one round of low-dose radiation and then continue…

This study looks at young women (ages 18-45) with hormone-sensitive breast cancer who are already on a 3-month hormone injection to suppress ovarian function. Researchers want to see if switching to a monthly injection keeps estrogen levels lower and more stable. About 100 partic…

This phase 3 trial tests whether a shorter course of radiation followed by chemotherapy and an immunotherapy drug (serplulimab) works better than the standard long-course chemoradiation for people with high-risk locally advanced rectal cancer. About 612 adults with specific high-…

This study tests whether a combination of targeted drugs and hormone therapy can keep advanced HER2-positive breast cancer under control after an initial powerful treatment. About 288 women with cancer that has spread or cannot be removed will receive maintenance therapy based on…

This study tests whether adding branched-chain amino acids (BCAAs) to a standard two-drug combination (lenvatinib and pembrolizumab) helps adults with advanced liver cancer that cannot be removed by surgery. About 234 participants will be randomly assigned to receive the drugs wi…

This study tests a drug called Vebreltinib given for 8 weeks before surgery in people with a specific type of lung cancer (stage IIA-IIIB NSCLC with METex14 skipping mutation). The goal is to see if the drug can shrink or control the tumor, making surgery more effective. About 30…

This study tests a combination of two experimental drugs (iparomlimab and tuvoraleimab) plus standard chemotherapy for people with advanced acral or mucosal melanoma, rare and aggressive skin cancers. About 48 adults who have had little or no prior treatment will receive the ther…

This study tests whether giving a daily probiotic mixture for 6 months can improve brain development in preterm infants who received antibiotics after birth. Researchers will enroll 116 babies and measure their developmental scores, gut bacteria changes, and inflammation markers.…

This study tests a new drug called SHR-1701 combined with chemotherapy and radiation for people with stage III lung cancer that cannot be removed by surgery. The goal is to see if adding this drug before or after standard treatment helps keep the cancer from growing. About 84 adu…

This study tests whether taking the oral drug everolimus after standard chemotherapy can help prevent breast cancer from coming back in people with a specific subtype of triple-negative breast cancer called LAR. The trial will enroll 904 women who have had surgery for early-stage…

This study tests a new combined treatment system for liver cancer that uses heat to destroy tumors. It will include 20 adults with primary or metastatic liver cancer who cannot have surgery. The goal is to see if the treatment is safe, how well it works at shrinking tumors, and h…

This study tests whether adding famitinib to SHR-A1811 works better than SHR-A1811 alone for people with a certain type of advanced breast cancer (HR+/HER2-) that no longer responds to CDK4/6 inhibitors. About 248 women aged 18-70 will take part. The goal is to see if the combina…

This study tests whether a new drug, sacituzumab tirumotecan (Sac-TMT), followed by standard chemotherapy (capecitabine), works better than capecitabine alone to keep early-stage, high-risk triple-negative breast cancer from returning. About 420 women without BRCA gene mutations …

This study tests a combination of two drugs, anlotinib and benmelstobart, as a second treatment option for people with advanced thyroid cancer that has spread or cannot be removed by surgery. About 23 adults whose cancer did not respond to or worsened after first treatment will r…

This study looks at whether adding diabetes medication to standard chemotherapy can help people with metastatic pancreatic cancer and diabetes live longer. About 210 adults with both conditions will receive either chemotherapy alone or chemotherapy plus active diabetes treatment.…

This study tests whether taking two drugs (imlunestrant and abemaciclib) before surgery can shrink tumors in people with a common type of breast cancer (ER+/HER2-). About 189 women aged 18-75 with early-stage breast cancer will join. The treatment is guided by a marker called Ki6…

This study tests whether a three-drug combination can help people with triple-negative breast cancer whose tumors stopped responding to immunotherapy. About 46 women will receive cromolyn, TQB2102, and panpulimab to see if tumors shrink or stop growing. The goal is to control the…

This early-phase study tests a combination of two drugs, becotatug vedotin and cetuximab, in people with a specific type of advanced colorectal cancer (RAS wild-type) that has not responded to prior treatments. The goal is to see if the combo can shrink tumors or slow the disease…

This study looks at men with advanced prostate cancer that has spread to other parts of the body. After 6 months of hormone therapy, those whose scans show the cancer is well-controlled may either continue hormone therapy alone or also have their prostate removed. The goal is to …

This study tests a combination of two drugs (sacituzumab tirumotecan and furmonertinib) in 45 adults with a specific type of advanced lung cancer (EGFR-mutant NSCLC) that has worsened after initial targeted therapy. The goal is to see if the combo can shrink tumors or slow diseas…

This study tests whether adding a traditional Chinese herbal formula (Qiqi Shengmai) to standard care can improve blood flow in the brains of people with moyamoya disease. About 66 adults aged 18 to 80 will receive either the herbal formula or a placebo for a set period. The goal…

This study looks at two powerful drugs, sacituzumab govitecan (SG) and trastuzumab deruxtecan (T-DXd), for people with a certain type of advanced breast cancer (HER2-low/TROP2-high). The goal is to find out which drug works best when given first and how to switch if the first sto…

This study tests whether adding all-trans retinoic acid (ATRA) to standard VAC chemotherapy improves outcomes for people with intermediate-to-high-risk rhabdomyosarcoma, a type of muscle cancer. About 106 participants aged 14 to 60 who have not had prior treatment will be enrolle…

This study tests a new combination of drugs given before surgery for women with a specific type of breast cancer (ER-positive, HER2-positive). The goal is to see if this chemo-free approach can shrink tumors enough to eliminate all signs of cancer at surgery. About 42 women with …

This study tests a new way to give radiation for advanced non-small cell lung cancer. The approach uses a mix of high and low radiation doses along with chemotherapy and immunotherapy before and after radiation. The goal is to shrink tumors more quickly and reduce the risk of lun…

This study tests a new drug combination for people with advanced soft tissue sarcoma that has not responded to earlier treatments. The treatment includes an immunotherapy drug (epalrotokewali) plus chemotherapy and radiation. The goal is to see if this approach can shrink tumors …

This study tests a combination of three drugs (sintilimab, bevacizumab, and chemotherapy) in people with a rare and aggressive type of stomach cancer that produces a protein called AFP. The goal is to shrink the tumor enough so it can be removed by surgery. About 46 adults with a…

This study tests a new approach for people with HER2-negative breast cancer that has spread to the liver and hasn't responded to prior treatments. It combines a special heat therapy (multi-mode thermal therapy) with immunotherapy to see if it can slow or shrink tumors. About 30 p…

This study tests a personalized approach for people with advanced esophageal cancer that cannot be removed by surgery. Doctors will use MRI scans to guide a custom combination of chemotherapy, radiation, and immunotherapy. The goal is to see if this tailored treatment can help ke…

This study tests a combination of two drugs, envafolimab and lenvatinib, as the first treatment for people with a type of kidney cancer (clear cell renal cell carcinoma) that has spread to the liver. The goal is to see if the combination shrinks liver tumors and improves survival…

This study tests a new drug, QLC5513, alone or with another drug (QL1706) in 60 women with advanced triple-negative breast cancer that has worsened after at least one prior treatment. The goal is to see if these drugs can shrink tumors or slow the cancer's growth. Participants wi…

This study tests whether a combination of hormone therapy, a CDK4/6 inhibitor, and anti-HER2 drugs can replace chemotherapy for women with a specific type of early-stage breast cancer (HR-positive, HER2-positive, lymph node-negative). About 1,500 participants will be randomly ass…

This study tests a treatment plan for people with liver cancer that is too large for a transplant but can still be removed by surgery. Before surgery, patients receive a liver-directed procedure (TACE) plus an immunotherapy drug (QL1706). After surgery, they continue QL1706 alone…

This study looks at how well the drug Toripalimab works as the first treatment for people with extensive-stage small cell lung cancer, a fast-growing lung cancer that has spread. Researchers will track 1,200 patients in China to see how long the cancer stays under control and how…

This study tests whether using a 3D-PTA drug sensitivity test to choose chemotherapy after surgery works better than standard chemo for people with stage II/III bile duct cancer. About 98 adults who had their tumor removed will be randomly assigned to either personalized chemo or…

This study looks at whether women with a common, early-stage breast cancer can safely take hormone-blocking drugs for only 2-3 years instead of the usual 5 years. About 2,900 women will be randomly assigned to either the shorter or standard treatment. The goal is to see if the sh…

This study tests different drug combinations before surgery for people with locally advanced colorectal cancer. The treatment is chosen based on the tumor's genetic and molecular features. The goal is to see if this personalized approach can eliminate the cancer before surgery, a…

This study tests whether a new combination of immunotherapy drugs (iparomlimab and tuvonralimab) plus chemotherapy works better than another immunotherapy plus chemotherapy for people with advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer. About 104 adults will…

This study tests whether adding bevacizumab to trastuzumab deruxtecan (T-DXd) helps control HER2-low breast cancer that has spread to the brain. About 140 adults with this condition will receive either T-DXd alone or T-DXd plus bevacizumab. The goal is to see which approach delay…

This study tests three treatment plans for people with a specific type of colorectal cancer (MSI-H/dMMR) that has spread locally but not to distant organs. The goal is to see if combining two immunotherapy drugs, or adding radiation to one immunotherapy drug, works better than on…

This study tests whether adding neratinib to the standard drug trastuzumab deruxtecan works better for HER2-positive breast cancer that has spread to the brain. About 202 women aged 18-70 will be randomly assigned to get the combination or the standard drug alone. The main goal i…

This study tests a new combination of two drugs (becotatug vedotin and pucotenlimab) in 20 adults with advanced penile cancer that has spread and is EGFR-positive. Participants must have failed or be unable to tolerate chemotherapy. The goal is to see if the treatment can shrink …

This study tests whether a new drug combination (fruquintinib plus chemotherapy) works better than the current standard (bevacizumab plus chemotherapy) for people with a specific type of advanced colorectal cancer that has a RAS mutation. About 224 adults aged 18 to 75 will be ra…

This study tests whether adding fluzoparib (a daily pill for one year) to standard treatment can help prevent breast cancer from returning in women with early-stage breast cancer who have inherited changes in HRR genes. About 334 women aged 18-75 will be randomly assigned to rece…

This study looks at whether a combination of ribociclib (a targeted drug) and hormone therapy can be as effective as chemotherapy followed by the same combo for people with a common type of early breast cancer (HR+/HER2-). Only patients whose blood tests show no signs of cancer D…

This study tests whether Huaier granules, a traditional Chinese medicine, can help lower certain tumor markers (CEA, CA125, CA153) in people with early-stage breast cancer. About 232 participants will be randomly assigned to receive Huaier granules or not, and researchers will co…

This study tests whether an artificial intelligence (AI) model can pick a more effective combination of targeted drugs for women with HER2-positive breast cancer before surgery. About 280 women will either receive the AI-chosen therapy or the standard drug combination. The main g…

This study tests if a targeted drug (dalpiciclib) combined with hormone therapy can replace chemotherapy for women with small but high-risk ER-positive breast cancer. About 2,288 participants will either receive the new drug combo or standard chemo followed by hormone therapy. Th…

This study tests whether a new combination of drugs (paclitaxel polymeric micelles, trastuzumab, pertuzumab, and adebelimab) works better than the standard taxane-based combination for people with advanced HER2-positive breast cancer. About 140 adults who have not had prior chemo…

This study tests a new drug combination (RC48 plus chemotherapy) against standard treatment (trastuzumab/inetetamab plus chemotherapy) in people with HER2-positive advanced breast cancer whose disease worsened after prior therapy with a topoisomerase I inhibitor antibody-drug con…

This study will test whether an artificial intelligence model can accurately detect and diagnose kidney tumors and cysts using standard CT scans that don't require contrast dye. Researchers will analyze scans from 10,000 patients to see if the AI can tell the difference between h…

This study tests whether finding and treating high-risk types of H. pylori bacteria can prevent stomach cancer. About 4,800 adults aged 40 and older will be followed for up to 10 years. Researchers will compare cancer rates between those who get the bacteria treatment and those w…

This study tests whether an AI-powered chatbot can increase HPV vaccination among 1,800 women aged 15-26 in China who have not yet been vaccinated. Participants are randomly assigned to use the chatbot or not, and researchers measure their vaccine confidence, hesitancy, and actua…

This study tests whether an AI-powered chatbot and smart reminders can encourage more high-risk adults (ages 45-74) in China to get a colonoscopy, the gold standard for detecting colorectal cancer early. Participants are split into two groups: one gets usual care, the other also …

This study tests whether Huaier Granules, a traditional Chinese medicine, can treat proteinuria (excess protein in urine) caused by two common lung cancer drugs, Bevacizumab and Anlotinib. About 40 adult lung cancer patients with mild to moderate proteinuria will take the granule…

This study tests whether adding Huaier Granule to standard care can reduce protein in the urine (proteinuria) in breast cancer patients who developed this side effect from immunotherapy or anti-angiogenic therapy. About 120 women aged 18-75 will be randomly assigned to receive ei…

This study tests whether adding Yueju Pill, a traditional Chinese medicine, to standard cancer treatment can improve quality of life for people with advanced biliary tract cancer. About 210 adults with this rare cancer will receive either Yueju Pill or a placebo alongside their u…

This study will compare two groups of people having an endoscopy: those who stop taking semaglutide (a diabetes/weight-loss drug) for one week before the procedure, and those who never took it. The goal is to see if stopping the drug reduces leftover food in the stomach and impro…

This study aims to see if a specific type of immune cell in cancer-free lymph nodes can predict how well PD-1 inhibitors work for people with advanced or recurrent esophageal cancer. Researchers will compare these cells to current methods to find a better way to forecast treatmen…

This study observes 400 adults with advanced HER2-negative breast cancer who have already received antibody-drug conjugates. Researchers will track how long patients stay cancer-free or alive after starting eribulin-based therapy. The goal is to understand real-world treatment ou…

This study looks at whether a simple blood test can help doctors decide the best treatment after surgery for stomach or gastroesophageal junction cancer. About 32 people with stage III or IVA cancer will give blood samples before and after surgery to check for tumor DNA. The goal…

This study looks at 100 people who needed surgery for a mesh infection after hernia repair. It compares removing all the mesh versus removing only part of it, to see which approach leads to fewer hernia comebacks and fewer repeat infections. The goal is to help doctors choose the…

This observational study aims to develop a system that combines genetic and clinical data to predict which patients with colorectal cancer that has spread to the liver are at high risk of the cancer coming back after surgery. Researchers will study 200 adults aged 18-75 who have …

This study tests whether using a transparent cap on the colonoscope during a second look at the lower colon helps doctors find more polyps (adenomas). About 614 adults aged 45 to 75 will take part. The goal is to see if this simple tool improves detection and reduces missed polyp…

This study looks at how three different anesthetics change brain activity and consciousness in 120 adults having non-cardiac surgery. Researchers will use EEG to measure brain waves and connections. The goal is to better understand how anesthesia works and find ways to monitor aw…

This observational study aims to see if a specific type of immune cell (Tpex) found in cancer-free lymph nodes can predict whether esophageal cancer will completely respond to immunotherapy given before surgery. Researchers will study 88 people with esophageal cancer who are sche…

This study is developing an artificial intelligence system to more accurately assess how clean the bowel is during a colonoscopy. Current AI methods assume the camera moves at a constant speed, which is not realistic. By using a special positioning system, the new approach accoun…

This study enrolls 30 people with cancer that has spread (metastasized). Researchers take a sample of the tumor and analyze its RNA to see if they can predict where the cancer originally started. No treatment is given; the goal is to see how accurate the RNA test is at identifyin…

This study will follow 3000 adults aged 40 and older who are at high risk for stomach cancer. Participants will provide a stool sample and have a normal stomach exam at the start. Researchers will track who develops stomach cancer over 10 years to see if a simple stool test can p…

This study looks at whether stopping GLP-1 medications (like Ozempic) for two weeks before an upper endoscopy can lower the chance of food staying in the stomach. Researchers will review medical records from over 16,000 people to see if a drug pause helps. The goal is to improve …

This study tests whether artificial intelligence can help more high-risk adults aged 40 to 64 get a colonoscopy, the best way to detect colorectal cancer early. About 400 participants will be split into two groups: one gets usual care, the other gets AI-assisted support from a te…

This study looks back at medical records of 150 people aged 90 or older who had planned hernia repair surgery with mesh. Researchers want to see how often serious complications happen and what factors might increase risk. The goal is to help doctors and patients make better decis…

This study is for women with breast cancer to see if special PET/MRI scans can predict how well their treatment will work. About 300 women will get two types of PET/MRI scans before and after two treatment cycles. The goal is to find which scan patterns match with good or poor tr…

This study will observe 460 diabetic adults who take semaglutide to see if those with nerve damage are more likely to develop gastric retention (stomach not emptying properly). Participants will be split into two groups based on whether they have neuropathy or not. The goal is to…