Could Early-Stage breast cancer patients skip chemo? new trial aims to find out

NCT ID NCT07213206

First seen Nov 01, 2025 · Last updated Jun 10, 2026 · Updated 23 times

Summary

This study tests whether a combination of hormone therapy, a CDK4/6 inhibitor, and anti-HER2 drugs can replace chemotherapy for women with a specific type of early-stage breast cancer (HR-positive, HER2-positive, lymph node-negative). About 1,500 participants will be randomly assigned to either the chemo-free regimen or standard chemo plus anti-HER2 therapy. The goal is to see if the new approach is as effective at preventing cancer from coming back while reducing side effects.

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