Chemo-Free hope: new drug combo may spare thousands from toxic treatment

This study tests whether a combination of targeted drugs and hormone therapy can replace chemotherapy for people with a specific type of early-stage breast cancer (HR-positive, HER2-positive, no lymph node spread). About 1,500 participants will receive either the standard chemo plus anti-HER2 drugs or a chemo-free regimen of a CDK4/6 inhibitor, hormone therapy, and anti-HER2 therapy. The goal is to see if the new approach works as well or better with fewer side effects.