Scientists probe Brain's 'Off Switch' under anesthesia

NCT ID NCT07644663

Not yet recruiting Knowledge-focused Sponsor: Fudan University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will give 120 surgery patients one of three anesthetics—propofol, dexmedetomidine, or esketamine—and use high-density EEG to measure brain activity while they are unconscious. The goal is to understand how each drug disrupts brain communication and to find markers that could help anesthesiologists monitor consciousness during surgery. Participants are healthy adults undergoing elective non-cardiac surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: propofol, dexmedetomidine, and esketamine
What this could lead to: If successful, this could lead to better ways to monitor consciousness during surgery, helping doctors ensure patients are properly anesthetized.
What could go wrong: This is an early-phase study focused on brain activity patterns, not on treating a disease. It may not directly change clinical practice, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIA ELECTROENCEPHALOGRAM (EEG)

Contacts and locations

Locations

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, 200032, China

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