COLORECTAL CANCER METASTATIC

This study is for people with colorectal cancer that has spread only to the liver and has a poor outlook. It compares standard chemotherapy plus a monoclonal antibody to the same treatment combined with a procedure that delivers chemotherapy directly to the liver using tiny beads…

This study aimed to test a new drug (LY3200882) combined with a standard chemotherapy (capecitabine) in people with advanced colorectal cancer that had stopped responding to previous treatment. The goal was to see if the combination could make the cancer respond again. However, t…

This early-phase trial tests a combination of two drugs, naptumomab estafenatox and durvalumab, in 120 adults with advanced or metastatic solid tumors (like breast, ovarian, lung, and pancreatic cancers) that have no curative options. The main goal is to find safe doses and under…

This study is testing two new drug combinations for people with a specific genetic mutation (KRAS G12C) in advanced colorectal cancer that has spread. One group gets the drugs as their first treatment, and another group gets them after standard treatment stops working. The goal i…

This study looks at whether adding tocotrienol (a compound related to vitamin E) to standard chemotherapy and bevacizumab can help control metastatic colorectal cancer better and cause fewer side effects. About 83 adults with advanced colon or rectal cancer will be randomly assig…

This study is for people with advanced colorectal cancer that has a specific genetic change called a KRAS mutation, and whose cancer has worsened after standard treatments. The goal is to test the safety of combining two drugs, AVUTOMETINIB and cetuximab, and find the best dose. …

This study tests a combination of three drugs (trifluridine/tipiracil, capecitabine, and bevacizumab) in people with metastatic colorectal cancer who have not had chemotherapy for their advanced disease and are not healthy enough for intensive treatment. The goal is to find a saf…

This study compares two treatments for colorectal cancer that has spread to the liver: needle ablation (using heat to destroy tumors) and surgical removal. 230 patients will be randomly assigned to one of the two procedures. The main goal is to see if the cancer comes back at the…

This study looks at how small changes in CT scan settings affect the way tumors are measured in people with colorectal cancer that has spread to the liver. About 169 participants will get an extra CT scan of their abdomen. The goal is to see if tumor measurements stay reliable ev…

This study looks at whether a blood test can detect signs of cancer returning after surgery for colorectal or appendix cancer that has spread to the abdomen. Researchers will collect blood samples from 55 patients before and after surgery to measure special markers in the blood. …