Double-Barreled attack: chemo plus targeted liver beads tested for stubborn colon cancer spread

NCT ID NCT04595266

Ongoing Disease control Sponsor: Grupo Espanol Multidisciplinario del Cancer Digestivo Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether adding a liver-directed chemoembolization procedure to standard chemotherapy can better shrink tumors in people with colorectal cancer that has spread only to the liver and has a poor outlook. About 48 participants will receive either chemotherapy alone or chemotherapy plus tiny beads loaded with irinotecan that are infused directly into the liver's blood supply. The main goal is to see if the combination leads to more tumor shrinkage at 6 months, with hopes of improving survival and enabling liver surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: FOLFOX chemotherapy plus a monoclonal antibody (anti-EGFR or bevacizumab), with or without irinotecan-loaded microspheres delivered directly to the liver via chemoembolization
What this could lead to: If this works, it could offer a more effective way to control colorectal cancer that has spread only to the liver, potentially shrinking tumors enough for surgery and extending survival.
What could go wrong: This is a small, early-phase (phase 2) trial with only 48 participants, so results may not apply to everyone. Adding liver chemoembolization also carries risks like liver damage, infection, or side effects from the extra chemotherapy.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm metastasis from malignant tumor of colon

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER METASTATIC LIVER METASTASIS COLON CANCER

Contacts and locations

Locations

Complejo Hospitalario de Navarra

Pamplona, Pamplona, Spain
H. Univ. Ramón y Cajal

Madrid, Madrid, 28044, Spain
Hospital Clínic

Barcelona, Barcelona, Spain
Hospital Parc Taulí

Sabadell, Barcelona, Spain
Hospital Universitari i Politècnic La Fe

Valencia, Valencia, 46026, Spain
Hospital Universitario 12 de Octubre

Madrid, Madrid, Spain
Hospital Universitario La Paz

Madrid, Madrid, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Barcelona, Spain

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