Can targeted liver chemo turn inoperable tumors into operable ones?
NCT ID NCT07764497
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This trial tests whether delivering chemotherapy directly to the liver through a pump, combined with standard systemic chemotherapy, can shrink liver tumors from colorectal cancer enough to allow surgery. The study enrolls people whose liver metastases are initially inoperable but who are physically able to undergo liver surgery. The main goal is to see how many participants become eligible for liver resection after this treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- hepatic arterial infusion of floxuridine and dexamethasone combined with standard systemic chemotherapy
- What this could lead to
- If successful, this approach could convert inoperable liver metastases into operable ones, potentially offering a path to surgery and improved long-term outcomes.
- What could go wrong
- This is a phase II trial, so the benefit is uncertain. The treatment involves invasive liver-directed therapy and may not shrink tumors enough for surgery in all patients, with risks from chemotherapy and the infusion procedure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sunnybrook Health Sciences Centre
RECRUITINGToronto, Ontario, M4N3M5, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New PET scan tracer could sharpen detection of liver spread in colorectal cancer
- New blood test could spot colon cancer before it spreads
- Can a 4-Week Low-Carb diet make liver surgery safer?
- New classification system may help guide treatment for colorectal cancer spread to liver
- Blood test could spare colon cancer patients from unnecessary chemo
- New study could map best surgical path for colorectal liver metastases