New blood test could spot colon cancer before it spreads

NCT ID NCT06342440

Recruiting now Diagnosis Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study is testing a new blood test called DENEB that looks for tiny molecules (microRNAs) to find colorectal cancer and precancerous polyps early. Researchers will collect blood samples from 2,000 people who are also getting a colonoscopy. The goal is to see if the blood test is accurate and could one day offer a simpler, less invasive way to screen for colorectal cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DENEB blood test (measures microRNA levels)
What this could lead to: If successful, this blood test could offer a simple, non-invasive way to catch colorectal cancer and precancerous polyps early, potentially saving lives through earlier treatment.
What could go wrong: This is an early-stage study still recruiting participants. The test may not be accurate enough to replace colonoscopy, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenomatous colon polyp colon dysplasia colonic neoplasm colorectal adenocarcinoma colorectal adenoma colorectal cancer colorectal carcinoma colorectal neoplasm colorectal serrated adenocarcinoma hereditary mixed polyposis syndrome polyp of large intestine polyposis syndrome, hereditary mixed, 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL ADENOCARCINOMA COLORECTAL ADENOCARCINOMA METASTATIC IN THE LIVER COLORECTAL ADENOMA AND CARCINOMA 1 COLORECTAL ADENOMA WITH MILD DYSPLASIA COLORECTAL ADENOMA WITH MODERATE DYSPLASIA COLORECTAL ADENOMA WITH SEVERE DYSPLASIA COLORECTAL ADENOMATOUS POLYP COLORECTAL CANCER COLORECTAL CANCER STAGE I COLORECTAL CANCER STAGE II COLORECTAL CANCER STAGE III COLORECTAL CANCER STAGE IV COLORECTAL DISORDERS COLORECTAL DYSPLASIA COLORECTAL NEOPLASMS COLORECTAL NEOPLASMS MALIGNANT COLORECTAL POLYP COLORECTAL SERRATED ADENOCARCINOMA

Contacts and locations

Locations

Barcelona University
RECRUITING

Barcelona, Spain
City of Hope Medical Center
RECRUITING

Monrovia, California, 91016, United States
IRCCS San Raffaele
RECRUITING

Milan, Italy
Mie University
RECRUITING

Mie, Japan
The First Affiliated Hospital of Dalian Medical University
RECRUITING

Dalian, China
University of California San Diego
RECRUITING

San Diego, California, 92093, United States

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