New cocktail aims to knock out rectal cancer before surgery
NCT ID NCT07281157
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing a combination of three drugs (liposomal irinotecan, capecitabine, and enlonstobart) plus a short course of radiation before surgery for people with locally advanced rectal cancer. The goal is to see if this approach can completely eliminate the tumor before surgery. The study plans to enroll 30 adults aged 18-75 with stage cT3-4 or node-positive rectal cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- liposomal irinotecan, capecitabine, and enlonstobart (a type of immunotherapy) plus short-course radiotherapy
- What this could lead to
- If successful, this combination could shrink or eliminate rectal tumors before surgery, potentially improving survival and reducing the need for more aggressive treatments.
- What could go wrong
- This is a small, early-phase study with only 30 participants and no comparison group. The combination may cause significant side effects, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ADVANCED COLORECTAL CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Tianjin Medical University Cancer Institute & Hospital
RECRUITINGTianjin, Tianjin Municipality, 300000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new drug combo shrink Hard-to-Treat colorectal tumors?
- New drug combo aims to outperform standard therapy for advanced colorectal cancer
- New cocktail of drugs aims to tackle tough colorectal cancer
- Cottonseed compound plus immunotherapy takes on tough colorectal cancer
- Triple therapy aims to wipe out rectal cancer before surgery
- New drug cocktail hopes to tackle advanced colon cancer