New hope for Hard-to-Treat cancers: experimental drug BMS-986523 enters human trials

NCT ID NCT07223047

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called BMS-986523, alone or with other cancer drugs, in people with advanced solid tumors (like lung, colorectal, or pancreatic cancer) that have a specific genetic change (KRAS mutation). The goal is to see if it is safe and works. About 252 adults will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BMS-986523
What this could lead to: If successful, this could point toward a new treatment option for people with advanced solid tumors that have KRAS mutations.
What could go wrong: This is an early-phase trial (Phase 1/2a) with a small number of participants, so safety and effectiveness are not yet proven. The drug may cause side effects or not work as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer colorectal cancer colorectal neoplasm lung neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID MALIGNANCIES COLORECTAL CANCER (CRC) NON-SMALL CELL LUNG CANCER (NSCLC) PANCREATIC DUCTAL ADENOCARCINOMA (PDAC)

Contacts and locations

Locations

BC Cancer Vancouver
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
Local Institution - 0006
NOT_YET_RECRUITING

Badalona, Barcelona [Barcelona], 08916, Spain
Local Institution - 0008
NOT_YET_RECRUITING

Hortaleza, Madrid, 28050, Spain
NEXT Oncology
RECRUITING

San Antonio, Texas, 78229, United States
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
START Mountain Region
RECRUITING

West Valley City, Utah, 84119, United States

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