New hope for Hard-to-Treat cancers: experimental drug targets KRAS mutation
NCT ID NCT07349537
First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 3 times
Summary
This early-phase trial is testing a new oral drug called RMC-5127, alone or combined with other drugs, in adults with advanced solid tumors that have a specific KRAS G12V mutation. The study includes people with lung, colorectal, and pancreatic cancers who have already tried standard treatments. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- RMC-5127 (oral tablet)
- What this could lead to
- If successful, this could lead to a new treatment option for people with hard-to-treat cancers that have a specific KRAS mutation.
- What could go wrong
- This is an early Phase 1 trial, so the drug may not work or could have serious side effects. It is only for patients who have already tried other treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Johns Hopkins
RECRUITINGBaltimore, Maryland, 21231, United States
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Laura and Isaac Perlmutter Cancer Center at NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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NEXT
RECRUITINGSan Antonio, Texas, 78229, United States
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NEXT - Dallas
RECRUITINGDallas, Texas, 75039, United States
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NEXT - Virginia
RECRUITINGFairfax, Virginia, 22031, United States
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START - San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
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START Midwest
RECRUITINGGrand Rapids, Michigan, 49546, United States
Contact Email: •••••@•••••
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Yale Cancer Center
RECRUITINGNew Haven, Connecticut, 06511, United States
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