Do we really need antibiotics after bladder removal? new trial investigates

NCT ID NCT06190197

Recruiting now Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether it is safe to skip preventive antibiotics after bladder removal surgery for muscle-invasive bladder cancer. Half of the 120 participants will take nitrofurantoin daily for 10–21 days after surgery, while the other half will receive no antibiotics. The goal is to compare rates of urinary tract infections in the first 90 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nitrofurantoin
What this could lead to: If successful, this could show that not all patients need antibiotics after bladder removal surgery, reducing unnecessary drug use and side effects.
What could go wrong: This is a very early-phase trial with only 120 people, so results may not apply broadly. The study focuses on infection rates, not long-term outcomes or survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infiltrating bladder urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ILEAL CONDUIT MUSCLE INVASIVE BLADDER CARCINOMA NEOBLADDER DIVERSION RADICAL CYSTECTOMY

Contacts and locations

Locations

University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55414, United States

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