MUSCLE-INVASIVE BLADDER CARCINOMA

This study is comparing two standard surgical methods for bladder cancer. It will see if patients do better with or without a temporary plastic tube (a ureteral stent) placed during surgery to remove the bladder. Researchers will track 70 patients for a year to measure complicati…

This is an early-stage safety study for a new type of personalized cancer vaccine. It is for patients with bladder or stomach cancer who have had surgery but still have tiny traces of cancer DNA in their blood, putting them at high risk for the cancer coming back. The goal is to …

This study is testing if a targeted drug called sacituzumab govitecan can help shrink tumors before surgery for patients with a rare and aggressive type of bladder cancer. The drug acts like a 'smart bomb,' attaching to cancer cells to deliver chemotherapy directly to them. The g…

This early-stage study is testing whether a new targeted drug, sacituzumab govitecan, can be safely combined with precise radiation therapy. The goal is to control muscle-invasive bladder cancer while allowing patients to keep their bladder, avoiding surgical removal. The study w…

This study is testing a combination of two drugs, futibatinib and durvalumab, given before surgery to remove the bladder. It is for patients with muscle-invasive bladder cancer who cannot receive the usual chemotherapy due to other health problems like kidney issues or heart fail…

This study is testing whether a combination of chemotherapy, immunotherapy, and radiation can effectively treat a rare form of muscle-invasive bladder cancer while allowing patients to keep their bladder. The treatment approach will be given to 20 participants with this specific …

This study is testing whether a combination of chemotherapy and immunotherapy can effectively treat muscle-invasive bladder cancer, with the goal of allowing patients to keep their bladder instead of needing surgery to remove it. About 36 adults with localized bladder cancer will…

This study is testing whether removing only the cancerous part of the bladder, instead of the entire bladder, is a safe and effective treatment for muscle-invasive bladder cancer. About 40 participants will receive standard chemotherapy before and after surgery, followed by the p…

This study is testing a new combination of two cancer drugs (enfortumab vedotin and pembrolizumab) given alongside targeted radiation therapy. The goal is to see if this approach can effectively control muscle-invasive bladder cancer for patients who are not candidates for, or wh…

This study is testing whether taking PET scan images 2.5 hours after injection, instead of the standard 1 hour, improves the detection of cancer spread to lymph nodes in patients with muscle-invasive bladder cancer. Researchers will compare the accuracy of the delayed images agai…

This study aims to collect blood and tissue samples to help develop a single blood test that can detect many different cancers early. Researchers will enroll 2,000 people, including those with cancer and those without, to create a reference set for testing. The goal is to validat…

This study is testing whether patients can safely skip taking preventive antibiotics after major surgery to remove the bladder for cancer. It compares the rate of urinary tract infections in patients who take a preventive antibiotic for 90 days after surgery versus those who take…

This study aims to create and test a counseling program to help bladder cancer patients manage sexual health problems that often arise after treatment. Researchers will first interview patients to understand their specific challenges and needs. Then, they will test the new suppor…