MUSCLE-INVASIVE BLADDER CARCINOMA

This early-stage trial tests a personalized cancer vaccine for people with bladder or gastroesophageal cancer who have tiny amounts of cancer still detectable after surgery. The vaccine is custom-made from each patient's unique tumor markers and aims to train the immune system to…

This early-stage trial tests a drug called sacituzumab govitecan (SG) given alongside a precise type of radiation therapy for people with muscle-invasive bladder cancer. The goal is to see if this combination is safe and can help patients keep their bladder instead of needing sur…

This study tests a combination of two drugs (enfortumab vedotin and pembrolizumab) plus radiation therapy for people with muscle invasive bladder cancer. The goal is to destroy the tumor without removing the bladder, offering an alternative to standard surgery. About 47 adults wi…

This study is for people with muscle-invasive bladder cancer that has not spread. It tests whether removing only the part of the bladder with cancer (partial cystectomy) plus nearby lymph nodes, along with standard chemotherapy before and after surgery, works as well as removing …

This study looks at whether it is safe to skip preventive antibiotics after bladder cancer surgery that creates a new way for urine to leave the body. About 120 adults with muscle-invasive bladder cancer will be randomly assigned to receive either the antibiotic nitrofurantoin or…

This study tests whether people with a rare form of muscle-invasive bladder cancer can keep their bladder by first receiving chemotherapy (with or without immunotherapy) and then a combination of radiation and low-dose chemotherapy. The goal is to see if this approach is feasible…

This study tests whether combining futibatinib and durvalumab before bladder removal surgery can help patients with muscle-invasive bladder cancer who cannot receive standard cisplatin chemotherapy. About 24 adults with a specific genetic marker (FGFR overexpression) will receive…

This study looks at whether placing a small tube (stent) in the ureter after bladder removal surgery reduces the risk of urinary tract infections. About 70 adults with bladder or pelvic cancer will be randomly assigned to receive a stent or not. Researchers will track infections …

This study is testing whether a combination of chemotherapy and immunotherapy can effectively treat muscle-invasive bladder cancer, with the goal of allowing patients to keep their bladder. Adults with localized bladder cancer will receive treatment and be closely monitored. If t…

This study looks at whether taking PET scans later (2.5 hours after injection) finds lymph node spread in muscle-invasive bladder cancer more accurately than standard scans (1 hour after). About 66 adults with this cancer will get both scans, and results will be compared to surgi…

This study collects blood and tissue samples from 2000 people—some with cancer, some without—to help researchers develop and improve blood tests that can detect many types of cancer early. Participants provide samples that are stored and later used to test new diagnostic methods.…

This study aims to understand the sexual health challenges faced by bladder cancer patients and develop a support program. Researchers will interview 30 patients to learn about their needs and preferences. The goal is to create a tailored intervention to improve sexual well-being…