New pill targets HER2 cancers in promising trial

NCT ID NCT06760819

Recruiting now Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This Phase 2 trial tests an oral drug called BAY 2927088 (sevabertinib) in about 111 adults with advanced solid tumors that have HER2 gene mutations. The drug aims to block the abnormal HER2 protein and stop cancer growth. Participants take a 20 mg tablet daily in 3-week cycles until their cancer worsens or side effects become too severe. The main goal is to see how many patients' tumors shrink or disappear.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BAY 2927088 (sevabertinib) tablet
What this could lead to: If successful, this could provide a new targeted treatment option for people with various HER2-mutated solid tumors that have stopped responding to standard therapies.
What could go wrong: This is an early Phase 2 study with only 111 participants, so results may not apply to everyone. The drug may cause side effects or fail to shrink tumors in many patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

biliary tract cancer Biliary Tract Neoplasms bladder transitional cell carcinoma breast cancer breast neoplasm cancer cervical cancer colorectal carcinoma colorectal neoplasm digestive system neoplasm endometrial cancer endometrium neoplasm Esophageal Neoplasms gallbladder neoplasm gastric neoplasm gastrointestinal stromal tumor ovarian cancer pancreatic neoplasm sarcoma Urinary Bladder Neoplasms Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS HER2 MUTATION

Contacts and locations

Locations

Aarhus University Hospital | Oncology Department - Clinical Research Unit
RECRUITING

Aarhus N, Central Jutland, 8200, Denmark
Aichi Cancer Center Hospital
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Asan Medical Center | Oncology
RECRUITING

Seoul, 05505, South Korea
Azienda USL IRCCS di Reggio Emilia_Arcispedale Santa Maria Nuova - S.C. Oncologia Provinciale
RECRUITING

Reggio Emilia, 42123, Italy
Beijing Cancer Hospital - Oncology Department
RECRUITING

Beijing, Beijing Municipality, 100142, China
Brigette Harris Cancer Pavilion at Henry Ford Cancer Center - Detroit
WITHDRAWN

Detroit, Michigan, 48202, United States
CHU Brest - Hopital La Cavale Blanche - service oncologie medicale
RECRUITING

Brest, Brittany Region, 29200, France
Centre Hospitalier Lyon Sud - Service oncologie medicale
RECRUITING

Pierre-Bénite, Auvergne-Rhône-Alpes, 69310, France
Centre Oscar Lambret - Service Oncologie
RECRUITING

Lille, Hauts-de-France, 59000, France
City of Hope - Duarte Cancer Center
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic - Oncology Department
RECRUITING

Cleveland, Ohio, 44195, United States
Clinica Universidad De Navarra | Madrid | Oncologia
RECRUITING

Madrid, Navarre, 28027, Spain
Dana-Farber Cancer Institute - Oncology Department
RECRUITING

Boston, Massachusetts, 02215, United States
Florida Cancer Specialists & Research Institute - Fort Myers Cancer Center - Gladiolus
RECRUITING

Fort Myers, Florida, 33908, United States
Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1
RECRUITING

Milan, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Oncologia Medica
RECRUITING

Roma, 00168, Italy
Fudan University Shanghai Cancer Center - Oncology Department
RECRUITING

Shanghai, Shanghai Municipality, 200000, China
Gynecology Oncology clinic at UW Medical Center - Montlake
WITHDRAWN

Seattle, Washington, 98195, United States
Hokkaido University Hospital
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan
Hopitaux Universitaires de Geneve - Oncology Department
RECRUITING

Geneva, 1205, Switzerland
Hospital Universitari Vall D Hebron | Oncologia Medica
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Fundacion Jimenez Diaz | Oncologia Medica
RECRUITING

Madrid, 28040, Spain
Hunan Cancer Hospital - Oncology Department
RECRUITING

Changsha, Hunan, 410013, China
ICM - Institut du Cancer de Montpellier - Val d'Aurelle - CIPP
RECRUITING

Montpellier, Occitanie, 34298, France
ICON Cancer Centre - Southport
RECRUITING

Southport, Queensland, 4215, Australia
Inselspital Bern - Universitätsklinik für Medizinische Onkologie
RECRUITING

Bern, 3010, Switzerland
Institut Bergonie - Unicancer Nouvelle Aquitaine - Service Oncologie medicale
RECRUITING

Bordeaux, New Aquitaine, 33000, France
Institut Catala D'oncologia | Hospitalet | Oncologia
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08908, Spain
Institut Gustave Roussy - Departement d'Innovation Therapeutique et d'Essais Precoces (DITEP)
RECRUITING

Villejuif, Île-de-France Region, 94805, France
Instituto Oncologico Dr. Rosell S.L. | Oncologia
RECRUITING

Barcelona, 08028, Spain
Istituto Europeo di Oncologia s.r.l - Ginecologia Oncologica Medica
RECRUITING

Milan, 20141, Italy
Kindai University Hospital
RECRUITING

Sakai, Osaka, 590-0197, Japan
Macquarie University Hospital - Oncology Department
RECRUITING

Sydney, New South Wales, 2109, Australia
McGill University Health Centre - Glen Site - Women Health's Research Unit
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
NSW Health - Blacktown Hospital
RECRUITING

Blacktown, New South Wales, 2148, Australia
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East (NCCHE) - Kashiwa Campus
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
Odense University Hospital | Svendborg Sygehus - Oncology Department
RECRUITING

Odense, Region Syddanmark, 5000, Denmark
Peking University First Hospital - Oncology Department
RECRUITING

Beijing, Beijing Municipality, 100034, China
Princess Margaret Cancer Centre - University Health Network - Department of Medical Oncology and Hematology
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
Profound Research -OMG - TriAtria Cancer Center
RECRUITING

Farmington Hills, Michigan, 48334, United States
Queen Elizabeth II Health Sciences Centre | Oncology
RECRUITING

Halifax, Nova Scotia, B3H 2Y9, Canada
Rigshospitalet Copenhagen University Hospital | Oncology Department
RECRUITING

Copenhagen, Capital Region, 2100, Denmark
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Samsung Medical Center - Oncology Department
RECRUITING

Seoul, 06351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System - Oncology Department
RECRUITING

Seoul, 03722, South Korea
Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department
RECRUITING

Hangzhou, Zhejiang, 310016, China
The Cancer Institute Hospital of JFCR
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan
The University of Texas MD Anderson Cancer Center - Texas Medical Center
RECRUITING

Houston, Texas, 77030, United States
UAB O'Neal Comprehensive Cancer Center - The Kirklin Clinic of UAB Hospital
RECRUITING

Birmingham, Alabama, 35233, United States
UW Health Carbone Cancer Center
RECRUITING

Madison, Wisconsin, 53792, United States
UniversitätsSpital Zürich (USZ) - Klinik für Medizinische Onkologie und Hämatologie
RECRUITING

Zurich, 8091, Switzerland
Zhongshan Hospital, Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200032, China

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