New drug STRO-004 takes on advanced cancers in early trial

NCT ID NCT07227168

Recruiting now Disease control Sponsor: Sutro Biopharma, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This early-phase study tests a new drug called STRO-004 in adults with advanced solid tumors that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in more patients, and combining STRO-004 with another drug (pembrolizumab). The main goals are to check safety and look for signs that the drug shrinks tumors.

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Conditions

The condition(s) this trial relates to.

cervical cancer colorectal cancer colorectal neoplasm endometrial cancer endometrium neoplasm esophageal cancer Esophageal Neoplasms gastric cancer gastric neoplasm head and neck squamous cell carcinoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma urothelial carcinoma Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL CANCER COLORECTAL CANCER ENDOMETRIAL CANCER ESOPHAGEAL CANCER GASTRIC CANCER HEAD AND NECK SQUAMOUS CELL CARCINOMA (HNSCC) NON-SMALL CELL LUNG CANCER (NSCLC) PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) UROTHELIAL CANCER

Contacts and locations

Locations

Georgetown University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Mass General Cancer Center
RECRUITING

Boston, Massachusetts, 02114, United States
NEXT Austin
RECRUITING

Austin, Texas, 78758, United States
NEXT San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
SCRI Denver
RECRUITING

Denver, Colorado, 80218, United States
SCRI FCS Sarasota
RECRUITING

Sarasota, Florida, 34232, United States
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
UC San Diego Moores Cancer Center
RECRUITING

San Diego, California, 92037, United States

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