New oral drug targets Cancer's growth engine in advanced tumours
NCT ID NCT03096054
First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time
Summary
This trial investigates an experimental oral drug, LY3143921 hydrate, which blocks a protein called Cdc7 that cancer cells need to divide. It is being tested in adults with advanced solid tumours, including colorectal, ovarian, lung, and pancreatic cancers, that have not responded to standard treatments. The main goals are to find the safest dose and understand the drug's side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an oral drug called LY3143921 hydrate that blocks a protein (Cdc7) involved in cancer cell growth
- What this could lead to
- If successful, this could lead to a new treatment option for advanced solid tumours that have stopped responding to standard therapies.
- What could go wrong
- This is an early phase I trial with a small number of participants, so the drug may not prove effective or may have significant side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Beatson West of Scotland Cancer Centre
Glasgow, G12 0YN, United Kingdom
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Northern Centre for Cancer Care
Newcastle upon Tyne, NE7 7DN, United Kingdom
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Northern Ireland Cancer Centre
Belfast, BT9 7JL, United Kingdom
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Western General Hospital
Edinburgh, EH4 2XU, United Kingdom
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