METASTATIC SOLID TUMORS

This is an early-stage study to test the safety and side effects of a new drug called MK-0472 for people with advanced or metastatic solid tumors. Researchers will give the drug alone and in combination with other cancer therapies to about 178 participants. The main goal is to fi…

This trial is testing whether an experimental drug called R-DXd can help control advanced cancers that have spread and stopped responding to standard treatments. The study will enroll 200 adults with specific advanced cancers including ovarian, cervical, kidney, and bladder cance…

This study is testing new combinations of experimental drugs for people with advanced solid tumors that have specific RAS mutations. Researchers want to see if combining a new type of drug called a RAS(ON) inhibitor with another cancer drug called ivonescimab is safe and can help…

This is the first study in humans testing a new oral cancer drug called ERAS-0015. Researchers want to find safe doses and see how the body processes the drug when given alone or with other treatments to 200 adults with advanced solid tumors that have spread and have specific RAS…

This is a first-in-human study to test the safety and find the right dose of a new drug called BGB-53038. It targets a specific genetic change (KRAS mutation) found in many advanced solid tumors like lung, colorectal, and pancreatic cancers. The drug will be tested alone and in c…

This is the first human study of an experimental drug called CKD-512. It aims to find a safe dose and see if the drug, given alone or with an existing immunotherapy (pembrolizumab), can help control advanced solid tumors. The study is for people whose cancer has continued to grow…

This study is testing a new drug called repotrectinib in children and young adults (up to age 25) with advanced or spreading cancers that have specific genetic changes (ALK, ROS1, or NTRK). The first part aims to find a safe dose. The second part will see if the drug can shrink t…

This is the first study in humans testing a new cancer drug called DS3610a. It aims to find a safe and tolerable dose for people with advanced solid tumors that have stopped responding to standard treatments. The study will enroll about 70 participants to monitor side effects and…

This is the first-ever study in people for a new experimental drug called AVZO-103. It aims to find a safe and effective dose for adults with advanced cancers that have spread, including bladder cancer. The study will test the drug alone and in combination with other therapies to…

This is the first study in humans of a new drug called INCA33890 for people with advanced or spreading solid tumors. Researchers will test different doses in 408 participants to find the safest amount and see how the body processes the drug. The main goals are to understand side …

This is the first study testing the experimental cancer drug ADCX-020 in people. Researchers will give increasing doses to 290 adults with advanced solid tumors that have spread or returned after standard treatments. The main goals are to find a safe dose and see early signs of w…

This is the first human study of a new experimental drug called SLV-324 for people with advanced solid tumors that have spread. The main goal is to find the safest and most effective dose by giving the drug to about 70 patients and closely monitoring them. Researchers will check …

This is the first human trial testing a new cancer drug called AVZO-1418. Researchers want to find the safest dose and see if it can shrink tumors in adults with advanced solid cancers that have spread or cannot be removed by surgery. The study will test the drug alone and possib…

This is the first human study of an experimental drug called SKB107 for people with advanced solid tumors that have spread to their bones. The main goal is to find a safe dose and see how the body handles the drug. It will enroll 90 adults whose cancer has progressed despite stan…

This is a first-in-human study to test the safety, side effects, and best dose of a new investigational drug called RO7566802. It will be given alone and in combination with an existing immunotherapy drug (atezolizumab) to up to 250 adults with advanced solid tumors that have spr…

This is the first study in people to test a new oral drug called ERAS-4001. It aims to find a safe dose and see how the body handles the drug in patients with advanced solid tumors that have specific KRAS mutations. The drug will be tested alone and in combination with other canc…

This early study is testing the safety of a new, one-time treatment for people with advanced solid tumors that have spread and are no longer responding to standard therapies. Participants receive an injection of tiny magnetic particles that travel to the tumor. A few hours later,…