New hope for Hard-to-Treat cancers: first human trial of ERAS-0015 begins

NCT ID NCT06983743

Recruiting now Disease control Sponsor: Erasca, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This early-stage trial tests a new oral drug called ERAS-0015, alone or with other cancer drugs, in 600 adults with advanced solid tumors that have certain RAS mutations. The main goals are to check safety, find the right dose, and see how the drug moves through the body. Researchers will also look for early signs of tumor shrinkage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ERAS-0015 (oral drug) alone or combined with pembrolizumab, panitumumab, gemcitabine, or nab-paclitaxel
What this could lead to: If successful, this could point toward a new treatment option for people with advanced solid tumors that have certain RAS mutations and no other good options.
What could go wrong: This is an early Phase 1 trial focused on safety and dosing, not yet on effectiveness. It is small and may not lead to a proven treatment. Side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal neoplasm metastatic malignant neoplasm neoplasm Neoplasm Metastasis non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC SOLID TUMORS

Contacts and locations

Locations

Florida Cancer Specalists
RECRUITING

Sarasota, Florida, 34232, United States
Massachusetts General Hospital (MG)
RECRUITING

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Providence Medical Group
RECRUITING

Santa Rosa, California, 95403, United States
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Texas at Tyler
RECRUITING

Tyler, Texas, 75701, United States

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