Blood test may let cancer patients take safe breaks from immunotherapy
NCT ID NCT07689812
First seen Jul 08, 2026 · Last updated Jul 24, 2026 · Updated 3 times
Summary
This trial investigates whether a sensitive blood test (Signatera) can detect when it is safe to pause immunotherapy in people with advanced solid tumors like lung cancer, melanoma, and colorectal cancer. Participants are randomly assigned to either continuous standard immunotherapy or intermittent therapy guided by the blood test. The goal is to see if the intermittent approach provides similar survival while potentially reducing side effects and treatment time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Signatera blood test (ctDNA monitoring)
- What this could lead to
- If successful, this approach could allow many patients to take breaks from immunotherapy without harming survival, reducing side effects and treatment burden.
- What could go wrong
- This is an early-stage concept; the strategy may not provide the same survival benefit as continuous therapy, and some patients might need to restart treatment sooner than expected.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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