MELANOMA (SKIN CANCER)

This study explores whether a low branched-chain amino acid diet (a type of protein-restricted diet) combined with an immunotherapy drug (anti-PD-1) is safe and effective for people with stage III melanoma that has spread to lymph nodes. About 80 participants will receive the die…

This early-stage study tests two drugs—alpelisib and pembrolizumab—together in people with metastatic breast cancer or melanoma that has spread. The main goal is to find a safe dose and watch for side effects. About 50 adults whose cancer has worsened after standard treatments wi…

This study tests whether people with early-stage melanoma (skin cancer) can safely avoid a second surgery to remove extra tissue around the original tumor. About 1,749 adults whose melanoma was already completely removed will be randomly assigned to either standard follow-up care…

This study tests whether adding two oral drugs, AMXT 1501 and DFMO, to standard treatments can help people with advanced solid tumors (melanoma or a type of breast cancer) that have stopped responding to prior therapies. About 92 adults will receive the drug combo alongside their…

This study tests a new oral drug, LNS8801, alone or with pembrolizumab, in people with advanced melanoma that has stopped responding to standard treatments. About 135 participants will be randomly assigned to one of three groups: LNS8801 alone, LNS8801 plus pembrolizumab, or stan…

This early-phase study tests a new drug called TGI-5, either alone or combined with the immunotherapy nivolumab, in people with advanced solid tumors (colorectal, melanoma, liver, or lung cancer) that cannot be removed by surgery. The main goals are to check safety and find the r…

This study tests a new treatment called EBNK-001, which uses donor natural killer (NK) cells to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive the NK cells along with ch…

This study tests a treatment using donor immune cells (CAR-NK cells) designed to attack cancer. The specific target on the cancer cells is chosen based on a biopsy of the tumor or a blood test. The goal is to see if this approach is safe and can shrink or control advanced solid t…

This study is testing whether giving a single dose of the immunotherapy drug pembrolizumab six weeks before surgery can help the immune system fight high-risk melanoma more effectively. It includes 49 adults with melanoma that hasn't spread on scans. After surgery, some patients …

This study tests whether one dose of the immunotherapy drug pembrolizumab, given before standard surgery, can shrink or eliminate tumors in people with stage IIb/c melanoma. About 30 adults with thick melanomas that haven't spread to lymph nodes will receive either pembrolizumab …

This study looks at blood samples from 20 adults with melanoma or other skin cancers to see if certain markers in the blood can predict how well treatment works or how long people live. Participants give blood during their regular care. The goal is to find better ways to monitor …

This study collects live tumor tissue from 2,000 people with various cancers to understand why some respond to immunotherapy and others don't. Participants give a biopsy as part of their normal care, and researchers analyze the samples in the lab. The goal is to develop better wa…

This study is looking at 200 people who have suspicious skin moles that need to be removed. Researchers will use a special microscope to examine the moles and also perform genetic tests on the removed tissue. The goal is to see if combining these methods can help doctors tell the…

This study is building a platform to better understand a person's risk of developing cancer or having it come back. Researchers will analyze blood samples from 850 people with certain cancers to find genetic markers, immune system changes, and other biological clues. The goal is …

This study looks at how immune checkpoint inhibitors (a type of immunotherapy for melanoma) might affect sex hormones and fertility in men and women. Researchers will collect blood samples and questionnaires from 80 participants during their regular treatment visits. No new treat…

This study looks at how certain cancer immunotherapies (anti-PD-1 drugs) might affect bone strength. Researchers will measure bone density and blood markers in 25 adults receiving these treatments for cancers like melanoma, lung, or breast cancer. The goal is to understand if the…