Engineered donor cells take aim at Hard-to-Treat cancers
NCT ID NCT07410494
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new approach using immune cells from healthy donors, engineered to recognize and attack cancer cells. The target is chosen based on each participant's tumor profile. The trial includes 85 adults with advanced solid tumors that have not responded to standard treatments. Participants receive either a single-target or dual-target cell product, along with chemotherapy to prepare the body.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Donor-derived CAR-NK cells (engineered immune cells) with chemotherapy (fludarabine and cyclophosphamide) and IL-2
- What this could lead to
- If successful, this could offer a new treatment option for people with advanced solid tumors that have stopped responding to standard therapies.
- What could go wrong
- This is an early-phase trial (Phase 1/2) with only 85 participants, so results may not apply to everyone. Risks include side effects from chemotherapy and the CAR-NK cells, and the treatment may not shrink tumors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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District One Hospital
RECRUITINGBeijing, Beijing Municipality, 086-373, China
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