New pill combo aims to fight advanced cancers that stopped responding to prior therapies

NCT ID NCT07287917

Recruiting now Disease control Sponsor: Aminex Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This study tests two oral drugs, AMXT 1501 and DFMO, given alongside standard treatments for people with advanced solid tumors (breast cancer or melanoma) that have worsened after prior therapies. The goal is to find a safe dose and see if the combination helps shrink tumors or slow disease. About 92 adults will take part.

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Conditions

The condition(s) this trial relates to.

breast neoplasm cutaneous melanoma estrogen-receptor positive breast cancer melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HER2-LOW HORMONE RECEPTOR POSITIVE BREAST CANCER MELANOMA (SKIN CANCER)

Contacts and locations

Locations

Laguna Clinical Research Associates
RECRUITING

Laredo, Texas, 78041, United States
Lumi Research
RECRUITING

Houston, Texas, 77090, United States
Minnesota Oncology-Sarah Cannon Research Institute
RECRUITING

Maple Grove, Minnesota, 55369, United States
START Cancer Research New York-Long Island
RECRUITING

Lake Success, New York, 11042, United States
START Los Angeles
RECRUITING

Los Angeles, California, 90025, United States
START Mountain Region
RECRUITING

West Valley City, Utah, 84119, United States
Sarah Cannon Research Institute Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Skin Cancer Institute
RECRUITING

Englewood, Colorado, 80113, United States
Texas Oncology
RECRUITING

Austin, Texas, 78731, United States
Texas Oncology - Dallas SCRI
RECRUITING

Dallas, Texas, 75246, United States
University of Arizona
RECRUITING

Tucson, Arizona, 85724, United States
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Texas-MD Anderson
RECRUITING

Houston, Texas, 77030, United States
University of Wisconsin-Madison Carbone Cancer Center
RECRUITING

Madison, Wisconsin, 53706, United States
Vanderbilt-Ingram Cancer Institute
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Cancer Specialists-Fairfax
RECRUITING

Fairfax, Virginia, 22031, United States
Wayne State University - Barbara Ann Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States

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