MELANOMA (SKIN CANCER)

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study tests whether giving three drugs (pucotenlimab, lenvatinib, and temozolomide) before surgery can shrink stage IIB/III acral melanoma, a type of skin cancer on the palms, soles, or under nails. About 30 adults will receive the combination for three 3-week cycles, then h…

This study tests whether a magnetic tracer (Magtrace) works as well as the standard radioactive dye plus blue dye for finding sentinel lymph nodes in people with melanoma. About 254 adults will get both tracers before surgery, and doctors will compare how often each method finds …

This study tests a special PET scan that uses a radioactive probe to detect PD-L1, a protein on tumor cells. It aims to help doctors identify which patients with lung cancer, melanoma, or other solid tumors are most likely to benefit from immunotherapy. About 40 adults will recei…

This study looks at 5 different smartphone programs designed to help people who have had melanoma (a serious skin cancer) protect themselves from the sun. About 150 participants will wear a UV sensor and activity tracker for a week, then use one of the phone programs for 8 weeks.…

This study tests a new rehabilitation program for people with melanoma, a serious skin cancer. The program includes exercises and support before and after surgery to help patients regain strength and confidence. The study will include 30 adults who are scheduled for surgery after…

This study tests whether using a Fitbit and weekly symptom surveys can help doctors remotely monitor cancer patients receiving immunotherapy. About 40 adults with advanced melanoma will participate. The goal is to see if this digital tool is easy to use and improves symptom manag…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health and find the right follow-up care. The goal is to see if this program improves how confident and capable survi…

This study aims to develop a blood test that can predict whether a patient with certain cancers (like lung, skin, or breast cancer) will benefit from immunotherapy. Researchers will analyze a specific type of white blood cell (neutrophils) from blood samples taken before treatmen…

This study looks at whether tiny particles in the blood, called extracellular vesicles, can help predict how well immunotherapy works for people with advanced lung cancer or melanoma. Researchers will collect blood samples from 378 patients before and during standard treatment. T…

This study examines stored tissue samples from 20 melanoma patients to see if interactions between fat cells and immune cells near the tumor can predict whether the cancer will spread. Researchers will analyze the arrangement of these cells and test their effects in the lab. The …