Scientists harness Patients' own immune cells to attack Treatment-Resistant melanoma

This study tests a therapy called Perkileucel, made from a patient's own immune cells (tumor-infiltrating lymphocytes). These cells are collected from a surgically removed melanoma tumor, grown in a lab, and then infused back into the patient. Before the infusion, patients receive a short course of chemotherapy to prepare their body. The goal is to see if this personalized cell therapy can shrink or control melanoma that has not responded to immune checkpoint inhibitors. The trial involves 10 adults with advanced melanoma and includes close monitoring for safety and effectiveness over several years.