New hope for kids with rare cancers: targeted drug repotrectinib enters trial

NCT ID NCT04094610

Recruiting now Disease control Sponsor: Turning Point Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called repotrectinib in children and young adults (up to age 25) with advanced solid tumors, lymphoma, or brain tumors that have specific gene changes (ALK, ROS1, or NTRK1-3). The goal is to find the safest dose and see if the drug shrinks tumors. Participants must have a confirmed gene change and be in good enough health to receive the treatment.

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Conditions

The condition(s) this trial relates to.

ALK-positive anaplastic large cell lymphoma anaplastic large cell lymphoma central nervous system cancer central nervous system neoplasm glioblastoma glioma inflammatory myofibroblastic tumor lymphoma metastatic malignant neoplasm neoplasm Neoplasm Metastasis NTRK fusion positive cancer primary brain neoplasm sarcoma solitary fibrous tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED SOLID TUMORS LYMPHOMA METASTATIC SOLID TUMORS PRIMARY CNS TUMORS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Alder Hey Children's NHS Foundation Trust
RECRUITING

Liverpool, England, L12 2AP, United Kingdom
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Centre Hospitalier Universitaire D'Angers
RECRUITING

Angers, 49933, France
Centre Hospitalier Universitaire de Bordeaux - Groupe Hospitalier Pellegrin
RECRUITING

Bordeaux, 33076, France
Children'S Hospital Of Eastern Ontario
RECRUITING

Ottawa, Ontario, K1H 8L1, Canada
Children's Health Queensland Hospital and Health Service
RECRUITING

South Brisbane, Queensland, 4101, Australia
Children's Healthcare of Atlanta - Egleston Hospital
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado - Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles
RECRUITING

Los Angeles, California, 90027-6062, United States
Children's Hospital of Philadelphia-Center for Childhood Cancer Research
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Richmond at VCU
WITHDRAWN

Richmond, Virginia, 23219, United States
Clinica Universidad de Navarra
RECRUITING

Madrid, 28022, Spain
Clínica Universidad de navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Dana Farber Cancer Institute.
RECRUITING

Boston, Massachusetts, 02215, United States
Fondazione IRCCS - Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Great Ormond Street Hospital For Children NHS Foundation Trust
RECRUITING

London, WC1N 3JH, United Kingdom
HM Sanchinarro University Hospital
RECRUITING

Madrid, 28050, Spain
Hospital Infantil Universitario Nino Jesus
RECRUITING

Madrid, 28009, Spain
Hospital Sant Joan De Deu
RECRUITING

Esplugues de Llobregat, Barcelona, 08950, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 8035, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario Y Politecnico La Fe
RECRUITING

Valencia, 46026, Spain
Hôpitaux Universitaires de Marseille Timone
RECRUITING

Marseille, 13385, France
Institut Gustave-Roussy
RECRUITING

Villejuif, 94805, France
Institut d Hematologie et d Oncologie Pediatriques
RECRUITING

Lyon, 69373, France
KK Women's and Children's Hospital
RECRUITING

Singapore, 229899, Singapore
Levine Children's Hospital- Pediatric Neuro-Oncology
RECRUITING

Charlotte, North Carolina, 28203, United States
Local Institution - 2102
COMPLETED

New York, New York, 10065, United States
Local Institution - 2104
COMPLETED

Houston, Texas, 77030, United States
Local Institution - 2105
COMPLETED

Orlando, Florida, 32806, United States
Local Institution - 2110
COMPLETED

New Brunswick, New Jersey, 08901, United States
Local Institution - 2112
COMPLETED

Cleveland, Ohio, 44195, United States
Local Institution - 2114
COMPLETED

Hershey, Pennsylvania, 17033, United States
Local Institution - 2120
COMPLETED

Orlando, Florida, 32827, United States
Local Institution - 4302
NOT_YET_RECRUITING

Rome, 00165, Italy
Local Institution - 4403
COMPLETED

Birmingham, B4 6DH, United Kingdom
Local Institution - 6103
COMPLETED

Westmead, New South Wales, 0, Australia
Local Institution - 6104
RECRUITING

Randwick, New South Wales, 2031, Australia
Local Institution - 6105
NOT_YET_RECRUITING

Barcelona, 08014, Spain
Local Institution - 6106
NOT_YET_RECRUITING

Madrid, 28009, Spain
Local Institution - 6107
NOT_YET_RECRUITING

Valencia, 46026, Spain
Local Institution - 6108
NOT_YET_RECRUITING

Villejuif, 94805, France
Local Institution - 6109
NOT_YET_RECRUITING

Paris, 75005, France
Local Institution - 6110
NOT_YET_RECRUITING

Marseille, 13385, France
Local Institution - 6111
NOT_YET_RECRUITING

Lyon, Rhone, 69008, France
Local Institution - 6112
NOT_YET_RECRUITING

Nantes, 44093, France
Local Institution - 6113
WITHDRAWN

Padova, 35128, Italy
Local Institution - 6114
WITHDRAWN

Torino, 10126, Italy
Local Institution - 6303
COMPLETED

Seoul, Seodaemun-gu, 03722, South Korea
Local Institution - 6304
COMPLETED

Seoul, 06351, South Korea
Maine Medical Center
RECRUITING

Scarborough, Maine, 04074, United States
National Taiwan University Hospital
RECRUITING

Taipei, 100225, Taiwan
National University Hospital
RECRUITING

Singapore, 119228, Singapore
Perth Childrens Hospital
RECRUITING

Nedlands, Western Australia, 6009, Australia
Rigshospitalet - Glostrup
RECRUITING

Copenhagen, 2100, Denmark
Royal Hosp. for Children
RECRUITING

Glasgow, G51 4TF, United Kingdom
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
St Justine Hospital
RECRUITING

Montreal, Quebec, H3T 1C5, Canada
St. Jude Children's Research Hospital
RECRUITING

Memphis, Tennessee, 38015, United States
Stollery Children'S Hospital
RECRUITING

Edmonton, Alberta, T6G 2B7, Canada
Taipei Medical University Hospital
RECRUITING

Taipei, 11031, Taiwan
The Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom
The University of Texas Southwestern Medical Center - Harold C Simmons Comprehensive Cancer Center
RECRUITING

Dallas, Texas, 75390, United States
University Hospital of Wales
RECRUITING

Cardiff, CF14 4XW, United Kingdom
University Of Calgary
RECRUITING

Calgary, Alberta, T3B 6A8, Canada
University of California at Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
Washington University School of Medicine in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

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