LOCALLY ADVANCED

This study is testing a new, one-time treatment for pancreatic cancer that cannot be removed by surgery. Doctors inject a radioactive 'glue' directly into the tumor to deliver targeted radiation, while patients continue their standard chemotherapy. The main goals are to see if th…

This study is testing a personalized treatment approach for people with locally advanced non-small cell lung cancer (NSCLC). It combines a new two-drug immunotherapy regimen (cemiplimab and fianlimab) with targeted radiation therapy. The goal is to see if this combination can bet…

This study is testing whether combining precise radiation therapy with a wearable device that creates electric fields around the tumor can slow the growth of locally advanced pancreatic cancer. All 48 participants will receive five days of targeted radiation while wearing the dev…

This study is testing whether a digital app that lets patients report their symptoms weekly helps doctors better manage side effects for people taking two cancer drugs (cabozantinib and nivolumab) for advanced kidney cancer. It involves 83 adults who are starting this specific dr…

This study is testing a new oral drug, PC14586 (rezatapopt), for people with advanced solid tumors that have a specific mutation in a gene called TP53 (Y220C). The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The trial is enrolling up…

This is the first-ever study in people for a new experimental drug called AVZO-103. It aims to find a safe and effective dose for adults with advanced cancers that have spread, including bladder cancer. The study will test the drug alone and in combination with other therapies to…

This early-stage study is testing a new oral medication called REC-1245 for people with advanced cancers that have spread or cannot be removed by surgery. The main goals are to find a safe dose, see how the body processes the drug, and check for early signs that it might help shr…

This is the first human trial testing a new cancer drug called AVZO-1418. Researchers want to find the safest dose and see if it can shrink tumors in adults with advanced solid cancers that have spread or cannot be removed by surgery. The study will test the drug alone and possib…

This study is testing if a more precise, faster radiation treatment can better control advanced lung cancer that cannot be surgically removed. It will compare this new approach to the current standard method, both combined with chemotherapy and a year of immunotherapy. The main g…

This study is testing a new method to check if breast cancer has spread to lymph nodes after chemotherapy. Researchers will mark a cancerous lymph node before treatment, then remove it along with a few others after chemotherapy to see if this smaller procedure is as accurate as r…