LOCALLY ADVANCED

This study tests a new drug called AVZO-103 in people with advanced bladder cancer or other solid tumors that have spread. The drug is designed to attack cancer cells directly. The main goals are to find a safe dose and see if it shrinks tumors. About 355 adults will take part.

This study tests a new drug called PC14586 (rezatapopt) in people with advanced or spreading solid tumors that have a specific change in the TP53 gene (Y220C mutation). The goal is to see if the drug is safe and works against these cancers. About 300 adults (and some teens after …

This study tests a new drug, CUE-101, alone or with pembrolizumab, in 30 people with newly diagnosed, advanced HPV-16 head and neck cancer that cannot be surgically removed. The goal is to see if these treatments can boost the body's immune cells to fight the tumor before standar…

This study looks at whether having patients report their symptoms weekly through a digital app helps doctors make better treatment decisions. It involves 83 adults with advanced kidney cancer who are starting a combination of two drugs (cabozantinib and nivolumab). The goal is to…

This study tests a new drug called AVZO-1418 in people with advanced solid tumors that have spread. The goal is to find a safe dose and see if it shrinks tumors. About 430 adults will take part. The drug is given through a vein, alone or with other treatments.

This study tests an experimental daily pill, REC-1245, in 170 adults with advanced solid tumors or lymphomas that have not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors or slow their growth. Participants will take the pill…

This study tests whether adding tumor treating fields (TTF) to targeted radiation therapy can slow tumor growth in people with locally advanced pancreas cancer. Participants receive radiation for five days and wear a device that delivers low-intensity electric fields for at least…

This study tests a new way to give radiation therapy (using PET scans to target smaller areas) along with standard chemo and an immunotherapy drug (durvalumab) for people with stage III lung cancer that cannot be removed by surgery. About 110 adults will be randomly assigned to e…

This study tests whether two immunotherapy drugs (cemiplimab and fianlimab) given before radiation can shrink tumors in people with locally advanced non-small cell lung cancer who cannot have surgery. About 76 participants will receive three cycles of the drug combination, then r…

This early study tests a new treatment for pancreatic cancer that cannot be removed by surgery. Ten participants will receive a single injection of a radioactive implant directly into their tumor, along with standard chemotherapy. The goal is to see if the combination is safe and…

This study tests a new type of radiation called lattice therapy for people with large, hard-to-treat tumors. The goal is to see if it can shrink tumors better and with fewer side effects than standard radiation. About 37 adults with advanced solid tumors will receive this treatme…

This study looks at a less invasive technique called target axillary dissection (TAD) to check if cancer has spread to lymph nodes after chemotherapy in people with locally advanced breast cancer. The goal is to see if TAD is accurate enough to replace more extensive lymph node r…