New pill targets rare cancer mutation in early trial

NCT ID NCT04585750

Recruiting now Disease control Sponsor: PMV Pharmaceuticals, Inc Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 4 times

Summary

This study tests a new drug called rezatapopt (PC14586) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The drug is designed to reactivate the p53 protein, which normally helps stop cancer growth. The trial will also test rezatapopt combined with the immunotherapy pembrolizumab. About 300 participants will be enrolled to check safety, dosing, and whether the drug shrinks tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: rezatapopt (PC14586) and pembrolizumab
What this could lead to: If successful, this could lead to a new targeted treatment option for people with advanced cancers that have a specific TP53 Y220C mutation, potentially shrinking tumors or slowing disease progression.
What could go wrong: This is an early-phase trial (Phase 1/2) with a small number of participants, so the drug may not work as hoped or could cause unexpected side effects. The mutation is rare, so results may not apply to most cancer patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm cancer colorectal cancer colorectal neoplasm endometrial cancer endometrium neoplasm estrogen-receptor positive breast cancer gallbladder cancer gallbladder neoplasm head and neck cancer Head and Neck Neoplasms HER2 positive breast carcinoma Her2-receptor negative breast cancer hormone receptor-positive breast cancer lung cancer lung neoplasm metastatic malignant neoplasm Neoplasm Metastasis non-small cell lung carcinoma ovarian cancer prostate cancer small cell lung carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED MALIGNANT NEOPLASM ADVANCED SOLID TUMOR BREAST CANCER COLORECTAL CANCER ENDOMETRIAL CANCER ER/PR POSITIVE BREAST CANCER ER/PR(+), HER2(-) BREAST CANCER GALL BLADDER CANCER HEAD AND NECK CANCER HER2 + BREAST CANCER HER2-NEGATIVE BREAST CANCER HER2-POSITIVE BREAST CANCER LOCALLY ADVANCED LUNG CANCER METASTATIC CANCER METASTATIC SOLID TUMOR NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CARCINOMA NSCLC NSCLC (NON-SMALL CELL LUNG CANCER) OTHER CANCER OVARIAN CANCER PROSTATE CANCER SCLC SMALL CELL LUNG CANCER SMALL CELL LUNG CANCER ( SCLC ) SMALL CELL LUNG CARCINOMA TNBC TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

Locations

ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, Lombardy, Italy
Abramson Cancer Center of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Advent Health
RECRUITING

Orlando, Florida, 32803, United States
Asan Medical Center
RECRUITING

Seoul, South Korea
Asklepios Klinik Altona
RECRUITING

Hamburg, Free and Hanseatic City of Hamburg, Germany
CHU de Nîmes
RECRUITING

Nîmes, 30900, France
Centre Jean Perrin
RECRUITING

Clermont-Ferrand, Puy-de-Dôme, France
Centre Léon Bérard Centre Régional de Lutte Contre Le Cancer
RECRUITING

Lyon, France
Chris O'Brien Lifehouse Hospital
RECRUITING

Camperdown, New South Wales, Australia
Columbia University Medical Center
NOT_YET_RECRUITING

New York, New York, 10032, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duke University
RECRUITING

Durham, North Carolina, 27705, United States
EDOG Institut de Cancerologie de l'Ouest
RECRUITING

Saint-Herblain, Loire-Atlantique, France
Flinders Medical Center
RECRUITING

Bedford Park, South Australia, Australia
Florida Cancer Specialists South
RECRUITING

Port Charlotte, Florida, 33980, United States
Fondazione IRCCS Istituto Nazionale Dei Tumori
RECRUITING

Milan, Lombardy, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Rome, Lazio, Italy
Fondazione del Piemonte per l'Oncologia (IRCCS)
RECRUITING

Candiolo, Torino, Italy
Freeman Hospital
RECRUITING

Newcastle upon Tyne, Tyne and Wear, United Kingdom
Hospital Clinico Universitario de Valencia
RECRUITING

Valencia, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Humanitas San Pio X
RECRUITING

Milan, Italy
ICANS - Institut de cancérologie Strasbourg Europe
RECRUITING

Strasbourg, Bas-Rhin, France
IRCCS - lstituto Nazionale Tumori - Fondazione G. Pascale
RECRUITING

Naples, 80131, Italy
Institut Bergonie
RECRUITING

Bordeaux, Gironde, France
Institut Claudius Regaud
RECRUITING

Toulouse, Haute-Garonne, France
Institut Gustave Roussy
RECRUITING

Villejuif, Val-de-Marne, France
Institute Cancer De Lorraine
RECRUITING

Vandœuvre-lès-Nancy, 54519, France
Instituto de Investigacion Oncologica Vall d'Hebron (VHIO) - EPON
RECRUITING

Barcelona, Spain
Istituti Fisioterapici Ospitalieri - Istituto Nazionale Tumori Regina Elena
RECRUITING

Rome, Lazio, Italy
Istituto Clinico Humanitas
RECRUITING

Rozzano, Lombardy, Italy
Istituto Europeo Di Oncologia
RECRUITING

Milan, Lombardy, Italy
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Linear Clinical Research
RECRUITING

Nedlands, Western Australia, Australia
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mater Cancer Care Centre
RECRUITING

South Brisbane, Queensland, Australia
Medical Oncology Hematology Consultants
RECRUITING

Newark, Delaware, 19713, United States
Medical University of South Carolina
TERMINATED

Charleston, South Carolina, 29425, United States
Memorial Sloan Kettering
RECRUITING

New York, New York, 10065, United States
Monash Medical Centre
RECRUITING

Clayton, Victoria, Australia
NEXT Oncology-Hospital Quironsalud Barcelona
RECRUITING

Barcelona, Spain
National Cancer Center
RECRUITING

Seoul, South Korea
National Cancer Center of Singapore
RECRUITING

Singapore, 168582, Singapore
National University Hospital
RECRUITING

Kent Ridge, Singapore
Nationale Centrum für Tumorerkrankungen (NCT) Heidelberg
RECRUITING

Heidelberg, Baden-Wurttemberg, Germany
New Experimental Therapeutics - NEXT Oncology
RECRUITING

Austin, Texas, 78705, United States
New Experimental Therapeutics of San Antonio - NEXT Oncology
RECRUITING

San Antonio, Texas, 78229, United States
Oregon Health & Science University (OHSU)
RECRUITING

Portland, Oregon, 97210, United States
Rocky Mountain Cancer Center
RECRUITING

Denver, Colorado, 80218, United States
START MADRID_Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Madrid, Madrid, Spain
START MADRID_Hospital Universitario HM Sanchinarro - CIOCC
RECRUITING

Madrid, Madrid, Spain
START Rioja
RECRUITING

Rioja, Spain
Samsung Medical Center
RECRUITING

Seoul, South Korea
Sarah Cannon Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute UK
RECRUITING

London, Middlesex, United Kingdom
Seoul University Hospital
RECRUITING

Seoul, South Korea
Severance Hospital Yonsei University
RECRUITING

Seoul, South Korea
Texas Oncology
RECRUITING

Bedford, Texas, 76022, United States
The Cleveland Clinic Taussig Cancer Center
RECRUITING

Cleveland, Ohio, 44195, United States
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UCLA Jonsson Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90024, United States
USC Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
UT Southwest Simmons Cancer Center
RECRUITING

Dallas, Texas, 75390, United States
University of California Irvine Chao Family Comprehensive Cancer Center
WITHDRAWN

Irvine, California, 92868, United States
University of Miami - Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Nebraska Medical Center Buffet Cancer Center
NOT_YET_RECRUITING

Omaha, Nebraska, 68105, United States
University of Oklahoma
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States
University of Washington, Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
University of Wisconsin Carbone Cancer Center
RECRUITING

Madison, Wisconsin, 53705, United States
Universitätsklinikum Augsburg
RECRUITING

Augsburg, Bavaria, Germany
Universitätsklinikum Essen
RECRUITING

Essen, North Rhine-Westphalia, Germany
Universitätsklinikum Frankfurt
WITHDRAWN

Frankfurt am Main, Hesse, Germany
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
WellSpan York Cancer Center
RECRUITING

York, Pennsylvania, 17403, United States
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06519, United States

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