SCLC

This study tests an experimental drug called ZL-1310, alone or with other cancer medicines, in people with small cell lung cancer. The goal is to see if it is safe and can shrink tumors or slow the disease. About 339 adults with advanced or spreading small cell lung cancer will t…

This early-phase study tests a new drug called SLV-154 in about 70 people whose solid tumors (like head and neck, lung, breast, or ovarian cancer) have spread. The main goal is to find a safe dose and watch for side effects. Participants must have a confirmed diagnosis and be in …

This early-phase study tests a new drug called HLX3901 in people with advanced small cell lung cancer or neuroendocrine carcinoma that has not responded to other treatments. The drug is a special antibody designed to help the immune system attack cancer cells. The main goals are …

This study tests a new drug called PC14586 (rezatapopt) in people with advanced or spreading solid tumors that have a specific change in the TP53 gene (Y220C mutation). The goal is to see if the drug is safe and works against these cancers. About 300 adults (and some teens after …

This study follows about 300 people with metastatic small cell lung cancer whose first chemotherapy stopped working. Researchers want to see how well the drug Zepzelca works and what side effects occur when used in everyday medical practice. The main goal is to measure how many p…

This study tests a new drug, TUB-030, in adults with advanced solid tumors like head and neck, lung, breast, and colorectal cancers. The main goals are to find a safe dose and see if the drug can shrink tumors. Participants receive the drug every 3 weeks and are closely monitored…

This program offers access to an experimental drug called I-DXd for people with extensive-stage small cell lung cancer who have already tried at least two prior treatments. It is for patients who have no suitable treatment options and cannot join a clinical trial. The goal is to …

This study tests a new drug called JAB-8263 in adults with advanced solid tumors (like lung or ovarian cancer) or blood cancers (like leukemia) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 15…

This study tests a combination of two drugs (golidocitinib and a PD-1 inhibitor) as maintenance treatment for people with extensive-stage small cell lung cancer who haven't had treatment yet. The goal is to see if this combo can delay cancer growth or improve survival. About 20 a…

This study is testing whether a combination of two drugs, sacituzumab govitecan and berzosertib, can help shrink tumors in people with aggressive cancers that have stopped responding to standard treatments. It is for adults with specific cancers, including small cell lung cancer …

This study tests a new radioactive probe called PFD3 that targets a protein (DLL3) found on small cell lung cancer cells. Using PET/CT scans, doctors hope to see tumors more clearly and assess the cancer's spread. About 30 adults with confirmed small cell lung cancer will receive…