SCLC

This early-phase study is testing an experimental oral medication called MRT-2359 in people with advanced cancers that have run out of standard treatment options. The trial focuses on several types of solid tumors and lymphoma, particularly those driven by specific genes called L…

This study is testing whether adding two immunotherapy drugs (monalizumab and durvalumab) to standard chemotherapy helps people with small cell lung cancer live longer without their cancer getting worse. It includes two groups: people with newly diagnosed advanced cancer and peop…

This study is testing whether combining two existing drugs, MEDI4736 and olaparib, is safe and can help control advanced cancers that have spread or returned. It is enrolling 264 adults with specific types of ovarian, breast, lung, or stomach cancer who have not had certain prior…

This study is testing whether combining two drugs, lurbinectedin and berzosertib, can shrink tumors in people with aggressive small cell lung cancer or high-grade neuroendocrine cancers that have returned after prior treatment. The first part of the trial aims to find the safest …

This study aims to understand how a person's genetic makeup influences their response to the chemotherapy drug topotecan for small cell lung cancer. Researchers will analyze the genes of 600 patients to see if specific genetic variations predict how well the drug works or what si…