SCLC

This study tests an experimental oral drug, MRT-2359, in people with certain advanced cancers, including lung cancer and lymphoma, that are driven by MYC genes. The trial has two phases: first, finding a safe dose, and second, checking if the drug shrinks tumors. About 174 adults…

This study tests a combination of two drugs, MEDI4736 (an immunotherapy) and olaparib (a targeted therapy), in people with advanced solid tumors like ovarian, breast, lung, and stomach cancers. The goal is to see if the combo can shrink or stabilize tumors. About 264 participants…

This study tests whether combining two drugs, lurbinectedin and berzosertib, can shrink tumors in people with small cell lung cancer or high-grade neuroendocrine cancers. These cancers often stop responding to standard chemotherapy. The trial includes 37 adults and aims to find t…

This study looks at two ways to give radiation to people with cancer that has spread to the brain. All participants are also receiving immunotherapy. The standard approach gives a single high dose of radiation, while the experimental approach gives a lower dose over a few days. T…

This study looks at how small differences in genes (called SNPs) affect how well the drug topotecan works and its side effects in people with small cell lung cancer. Researchers will test 600 patients who are already taking topotecan to find gene patterns linked to better outcome…