New drug cocktail shows promise for tough cancers
NCT ID NCT02734004
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing a combination of three drugs—durvalumab (an immunotherapy), olaparib (a targeted therapy), and bevacizumab (a drug that blocks blood vessel growth)—in people with advanced solid tumors, including ovarian, breast, lung, and gastric cancers. The goal is to see if the combination can shrink or stabilize tumors. About 264 participants are enrolled, and the study is no longer recruiting new patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
durvalumab (MEDI4736), olaparib, and bevacizumab
What this could lead to
If successful, this combination could offer a new treatment option for patients with advanced solid tumors that have not responded to standard therapies.
What could go wrong
This is an early-phase trial (Phase 1/2) with a small number of participants, so results may not apply to all patients. The combination may cause significant side effects or fail to improve outcomes.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Research Site
Newnan, Georgia, 30265, United States
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Towson, Maryland, 21204, United States
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Boston, Massachusetts, 02114, United States
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Detroit, Michigan, 48202, United States
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St Louis, Missouri, 63110, United States
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Hilliard, Ohio, 43026, United States
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Philadelphia, Pennsylvania, 19104, United States
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Bordeaux, 33076, France
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Caen, 14076, France
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Clermont-Ferrand, 63011, France
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Dijon, 21079, France
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Marseille, 13385, France
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Nantes, 44202, France
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Paris, 75014, France
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Pierre Benit Cedex, 69495, France
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Toulouse, 31059, France
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Villejuif, 94805, France
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Haifa, 91096, Israel
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Jerusalem, 91031, Israel
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Petah Tikva, 49100, Israel
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Ramat Gan, 5265601, Israel
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Tel Aviv, 6423906, Israel
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Amsterdam, 1066 CX, Netherlands
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Amsterdam, 1081 HV, Netherlands
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Maastricht, 6229 HX, Netherlands
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Nijmegen, 6525 GA, Netherlands
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Rotterdam, 3075 EA, Netherlands
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Utrecht, 3584 CX, Netherlands
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Goyang-si, 10408, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06273, South Korea
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Seoul, 06591, South Korea
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Seoul, 135-710, South Korea
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Chur, CH-7000, Switzerland
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Lausanne, 1011, Switzerland
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Cambridge, CB2 0QQ, United Kingdom
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Dundee, DD1 9SY, United Kingdom
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Glasgow, G12 0YN, United Kingdom
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Greater London, SW3 6JJ, United Kingdom
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London, NW1 2PG, United Kingdom
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London, SE1 9RY, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Newcastle upon Tyne, NE7 7DN, United Kingdom
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Sutton, SM2 5PT, United Kingdom