New pill targets MYC cancers in early trial
NCT ID NCT05546268
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an experimental oral drug, MRT-2359, in adults with certain advanced cancers, including lung cancer, lymphoma, and other solid tumors driven by MYC genes. The first part finds the safest dose; the second part checks if the drug shrinks tumors. About 174 participants will take the drug daily in 28-day cycles.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Columbia University Irving Medical Centre
New York, New York, 10032, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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Henry Ford Cancer Institute
Detroit, Michigan, 48202, United States
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Honor Health Research Institute
Scottsdale, Arizona, 85258, United States
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MD Anderson Cancer Center
Houston, Texas, 77030-4009, United States
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Mary Crowley Cancer Research
Dallas, Texas, 75251, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10021, United States
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Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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South Texas Accelerated Research Therapeutics (START)
San Antonio, Texas, 78229, United States
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South Texas Accelerated Research Therapeutics (START) Midwest
Grand Rapids, Michigan, 49546, United States
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South Texas Accelerated Research Therapeutics (START) Mountain Region
West Valley City, Utah, 84119, United States
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University of California San Diego
San Diego, California, 92037, United States
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University of Kansas Cancer Center
Lawrence, Kansas, 66044, United States
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Virginia Cancer Specialists Research Institute
Fairfax, Virginia, 22031, United States
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Washington University
St Louis, Missouri, 63110, United States
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Yale University
New Haven, Connecticut, 06520, United States