Can spreading out brain radiation reduce side effects for immunotherapy patients?
NCT ID NCT05703269
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 29 times
Summary
This study looks at two ways to give radiation to brain tumors in people who are also receiving immunotherapy for cancers like lung, breast, kidney, or melanoma. The standard approach gives one high dose of radiation, while the experimental approach gives smaller doses over several days. The goal is to see if spreading out the radiation lowers the chance of side effects like brain swelling. About 58 adults with brain metastases will take part.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Aspirus Cancer Care - James Beck Cancer Center
Rhinelander, Wisconsin, 54501, United States
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Aspirus Cancer Care - Stevens Point
Stevens Point, Wisconsin, 54481, United States
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Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin, 54494, United States
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Aspirus Langlade Hospital
Antigo, Wisconsin, 54409, United States
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Aspirus Regional Cancer Center
Wausau, Wisconsin, 54401, United States
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Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina, 28025, United States
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Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203, United States
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Crossroads Cancer Center
Effingham, Illinois, 62401, United States
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Decatur Memorial Hospital
Decatur, Illinois, 62526, United States
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Genesys Hurley Cancer Institute
Flint, Michigan, 48503, United States
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Gibbs Cancer Center-Pelham
Greer, South Carolina, 29651, United States
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HSHS Saint Elizabeth's Hospital
O'Fallon, Illinois, 62269, United States
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Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, 31405, United States
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Lovelace Medical Center-Saint Joseph Square
Albuquerque, New Mexico, 87102, United States
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Lovelace Radiation Oncology
Albuquerque, New Mexico, 87109, United States
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Mercy Health - Perrysburg Hospital
Perrysburg, Ohio, 43551, United States
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Mercy Hospital South
St Louis, Missouri, 63128, United States
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Mercy Hospital Springfield
Springfield, Missouri, 65804, United States
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OSF Saint Francis Medical Center
Peoria, Illinois, 61637, United States
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Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605, United States
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Saint Francis Cancer Center
Greenville, South Carolina, 29607, United States
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Saint Francis Hospital
Greenville, South Carolina, 29601, United States
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Saint Joseph's/Candler - Bluffton Campus
Bluffton, South Carolina, 29910, United States
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Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301, United States
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Sanford Broadway Medical Center
Fargo, North Dakota, 58122, United States
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Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104, United States
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Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122, United States
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Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134, United States
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Spartanburg Medical Center
Spartanburg, South Carolina, 29303, United States
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Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, 48114, United States
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Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, 48197, United States
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Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106, United States
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Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154, United States
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
radiation therapy (single fraction vs fractionated stereotactic radiosurgery)
What this could lead to
If fractionated radiation works better, it could become a new standard to reduce brain swelling and other side effects for patients on immunotherapy.
What could go wrong
This is a small, early-phase study with only 58 participants, so results may not apply to everyone. The benefit may be small or not seen at all.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.