BRAIN METASTASES, ADULT

This study tests whether stereotactic radiosurgery (SRS), a precise form of radiation, can effectively treat brain metastases in people newly diagnosed with small cell lung cancer that has spread to the brain. About 62 participants will receive SRS, and researchers will track how…

This study tests whether people with brain metastases from solid tumors can avoid radiation therapy if their brain tumors shrink or stay stable with systemic treatments like immunotherapy, targeted therapy, or chemotherapy. About 45 participants will be monitored with regular bra…

This study tests whether giving focused radiation before surgery for large brain metastases works better than giving it after surgery. About 146 adults with solid tumors and one large brain metastasis will be randomly assigned to one of the two timing schedules. The main goal is …

This study tests whether giving a single dose of radiation before surgery for brain metastases can lower the chance of cancer spreading to the lining of the brain, compared to five doses after surgery. About 200 adults with brain tumors that can be removed will take part. The goa…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This study tests a three-part approach for people with breast cancer that has spread to the brain. First, they receive focused radiation (stereotactic radiosurgery) along with a drug called olaparib, which may make cancer cells more sensitive to radiation. After that, they get an…

This study is building a large database of MRI scans from 3000 adults with malignant brain tumors (gliomas, metastases, lymphomas). Researchers will train an artificial intelligence system to automatically identify and classify these tumors. The goal is to improve non-invasive di…

This study tests whether the seizure drug levetiracetam (Keppra) can prevent first-time seizures in people with brain metastases located in the motor cortex. About 150 adults who have never had a seizure will be randomly assigned to take the drug or receive standard care. The goa…

This Phase 2 trial tests a new type of radiation therapy designed to avoid key brain areas involved in memory and thinking. Sixty adults with 1 to 3 small brain metastases will receive cognitive-sparing stereotactic radiosurgery. The main goal is to see if this approach better pr…

This study compares intensive multi-disciplinary care (a team of specialists working together) to standard care for 40 adults with newly diagnosed brain metastases from solid tumors. The goal is to see if the team approach reduces symptom burden and helps patients better understa…

This study tests a lab technique called pharmacoscopy that quickly checks which drugs work best on a patient's own brain metastasis tissue. About 102 adults with brain metastases and few treatment options will have their tumor samples tested. The goal is to see if using this test…

This study is testing whether a special PET scan (using 18F-Fluciclovine) can help doctors see if brain tumors are responding to radiation treatment. About 46 adults with brain metastases will get the scan before and after stereotactic radiosurgery. The goal is to find a better w…

This study is testing a special imaging agent called 18F-fluciclovine to see if it can detect how well radiation therapy is working on large brain tumors that have spread from other cancers. About 20 adults with at least one untreated brain tumor larger than 2 cm will get PET/CT …

This study tests whether doing radiation planning and treatment on the same day can better target fast-growing brain metastases. About 60 adults with brain tumors that grow at least 1mm per week will be randomly assigned to receive radiation with a 1mm or 0mm safety margin. The g…

This phase 2 trial is testing whether CT and MRI scans can act as biomarkers to predict how patients with brain metastases respond to radiation therapy. About 90 adults with brain metastases who are scheduled for radiation will get scans before and after treatment. The goal is to…

This study aims to develop and test a new MRI technique to distinguish between actual tumor growth and changes caused by radiation treatment in people with brain metastases. Researchers will include both healthy volunteers and patients who have had stereotactic radiosurgery. The …

This study is creating a collection of blood samples from 300 adults with primary or metastatic brain tumors. Researchers will analyze immune cells in the blood to better understand these tumors. The goal is to provide a resource for future studies, not to test a new treatment.