BRAIN METASTASES, ADULT

This study is testing whether a precise type of radiation called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. About 62 adults with up to 20 brain tumors will receive SRS, and researchers will track how many are alive af…

This study tests whether adding the drug azeliragon to targeted radiation therapy can safely shrink brain tumors and keep them under control longer. About 46 adults with cancer that has spread to the brain will receive the combination. The goal is to improve tumor response and de…

This study is for people with breast cancer that has spread to the brain. It tests a treatment plan that starts with focused radiation plus a drug called olaparib, followed by an immunotherapy drug (durvalumab) and standard chemotherapy. The goal is to see if this combination is …

This study tests whether giving focused radiation before surgery for large brain tumors (over 2.1 cm) works better than giving it after surgery. About 146 adults with cancer that has spread to the brain will be randomly assigned to one of the two timing groups. The goal is to see…

This study tests an experimental oral drug called NEO212 in people with certain brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control the disease. About 134 adults will take part across t…

This study tests whether giving a single dose of radiation before surgery for brain metastases can lower the chance of cancer spreading in the brain's lining, compared to five doses after surgery. About 200 adults with brain tumors will be randomly assigned to one of the two appr…

This study will collect MRI scans from 3000 adults with brain tumors (like gliomas or metastases) to train an AI system. The goal is to help doctors identify tumor types more accurately without surgery. If successful, it could reduce the number of biopsies needed.

This study tests whether the seizure drug levetiracetam (Keppra) can prevent first-time seizures in people with brain metastases located in the motor cortex. About 150 adults who have never had a seizure will be randomly assigned to take the drug or receive usual care. The goal i…

This study compares intensive multi-disciplinary care to standard care for 40 adults with newly diagnosed brain metastases. The goal is to see if a coordinated team approach improves symptom burden and helps patients better understand their prognosis. Participants will report sym…

This study is for adults with brain metastases that are growing quickly. It tests whether doing radiation planning and treatment on the same day can better target the tumors. Participants will get either a standard or a tighter radiation margin. The goal is to see if same-day pla…

This study looks at whether CT and MRI scans can help predict how well brain tumors respond to radiation treatment. Researchers will scan 90 adults with brain metastases before and after radiation. The goal is to find imaging biomarkers that could guide personalized treatment in …

This study aims to develop a new MRI technique to help doctors tell the difference between tumor growth caused by cancer and growth caused by radiation treatment in people with brain metastases. Researchers will test this imaging method on 119 healthy volunteers and patients who …

This study tests a new approach called pharmacoscopy, which quickly analyzes a patient's own brain tumor cells in the lab to see which drugs kill the cancer while sparing healthy cells. The goal is to see if this personalized method helps patients with brain metastases who have r…

This study looks at whether a special imaging agent called 18F-fluciclovine can help doctors see if radiation therapy is working on large brain tumors that have spread from other cancers. About 20 adults with at least one untreated brain tumor larger than 2 cm will get PET/CT sca…

This study collects blood samples from 300 adults with primary or metastatic brain tumors treated at Duke Cancer Center. The samples are stored in a repository to help researchers study immune cells and other markers. Participants provide blood during their regular visits, with n…