BRAIN METASTASES, ADULT

This study tests whether adding the drug azeliragon to targeted radiation therapy can safely shrink brain tumors and keep them under control longer. It involves 46 adults with cancer that has spread to the brain. The goal is to improve tumor control without causing serious side e…

This phase 2 trial is testing a combination of two immunotherapy drugs (nivolumab and ipilimumab) plus two cycles of chemotherapy as a first treatment for people with advanced lung cancer that has spread to the brain. The study aims to see if this approach can control the cancer …

This early-phase study is testing whether a special PET scan (68Ga-PSMA-11) can effectively show tumor activity in people with high-grade gliomas or brain metastases. About 11 adults whose tumors are at least 1 cm and who are already scheduled for a biopsy or surgery will receive…

This study looks at two ways to give radiation to brain tumors in people who are also receiving immunotherapy for cancers like lung, breast, kidney, or melanoma. The standard approach gives one high dose of radiation, while the experimental approach gives smaller doses over sever…

This study looks at whether a ketogenic (high-fat, low-carb) diet is practical and beneficial for 24 adults with brain metastases who are scheduled for radiosurgery. Participants will follow either a ketogenic diet or a standard healthy diet for 16 weeks. Researchers will track d…

This observational study looks back at 700 patients from 15 hospitals in 2 countries to compare local treatments like surgery and radiation for brain metastases that spread from colorectal cancer. Researchers will track how long patients live and how long it takes for brain tumor…