Precision radiation may offer new hope for lung cancer that spread to the brain

NCT ID NCT05419076

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether stereotactic radiosurgery (SRS), a precise form of radiation, can effectively treat brain metastases in people newly diagnosed with small cell lung cancer that has spread to the brain. About 62 participants will receive SRS, and researchers will track how many are alive after 6 months. The goal is to see if SRS can control the brain tumors while avoiding the side effects of whole-brain radiation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: stereotactic radiosurgery (SRS) – a precise, high-dose radiation treatment
What this could lead to: If successful, SRS could become a standard treatment option for people with brain metastases from small cell lung cancer, potentially improving survival and reducing side effects compared to whole-brain radiation.
What could go wrong: This is a small, single-arm Phase 2 study with only 62 participants, so results may not apply to everyone. SRS may not control all brain metastases, and some patients may still need additional treatments.

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Conditions

The condition(s) this trial relates to.

brain cancer lung cancer lung neoplasm metastatic malignant neoplasm metastatic malignant neoplasm in the brain small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES BRAIN METASTASES, ADULT LUNG CANCER LUNG CANCER METASTATIC SMALL CELL LUNG CANCER SMALL CELL LUNG CARCINOMA

Contacts and locations

Locations

Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Suffolk - Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Memorial Sloan Kettering at Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States

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