New radiation approach aims to shield memory during brain tumor treatment

NCT ID NCT04343157

Recruiting now Symptom relief Sponsor: Jona Hattangadi-Gluth Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests a new type of radiation therapy designed to avoid key brain areas involved in memory and thinking. Sixty adults with 1 to 3 small brain metastases will receive cognitive-sparing stereotactic radiosurgery. The main goal is to see if this approach better preserves verbal memory and other cognitive functions compared to standard radiation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cognitive-sparing brain stereotactic radiosurgery (SRS)
What this could lead to: If successful, this approach could help preserve memory and thinking skills in people receiving radiation for brain metastases.
What could go wrong: This is a small, early-phase study with only 60 participants. It is not yet known if the cognitive benefits will be significant or if tumor control will be maintained.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer cancer metastatic malignant neoplasm in the brain neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES, ADULT CANCER NEUROCOGNITIVE FUNCTION

Contacts and locations

Locations

Moores Cancer Center
RECRUITING

San Diego, California, 92037, United States

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