HER2 + BREAST CANCER
Clinical trials for HER2 + BREAST CANCER explained in plain language.
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First-of-its-Kind pill targets Cancer's 'Guardian Gene' mutation
Disease control Recruiting nowThis study is testing a new oral drug, PC14586 (rezatapopt), for people with advanced solid tumors that have a specific mutation in a gene called TP53 (Y220C). The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The trial is enrolling up…
Matched conditions: HER2 + BREAST CANCER
Phase: PHASE1, PHASE2 • Sponsor: PMV Pharmaceuticals, Inc • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Zapping one tumor to keep others at bay: new approach for advanced breast cancer
Disease control Recruiting nowThis study is testing if using highly focused radiation on a single tumor that has started growing again can help people with metastatic breast cancer stay on their current effective drug treatments longer. Participants will receive this targeted radiation while continuing their …
Matched conditions: HER2 + BREAST CANCER
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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New drug trial targets Tough-to-Treat HER2 cancers, including brain spread
Disease control Recruiting nowThis is an early-stage study to find a safe and effective dose of a new drug called IAM1363 for people with advanced cancers that have specific changes in a protein called HER2. The trial will enroll about 243 adults whose cancer has worsened after standard treatments, including …
Matched conditions: HER2 + BREAST CANCER
Phase: PHASE1 • Sponsor: Iambic Therapeutics, Inc • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Radioactive drug seeks and attacks advanced breast cancer in first human test
Disease control Recruiting nowThis is the first time a new radioactive drug called [177Lu]Lu-ABY-271 is being tested in people. The study aims to see if it is safe and how it moves to tumors and organs in patients with advanced HER2-positive breast cancer that has spread. It will involve up to 21 participants…
Matched conditions: HER2 + BREAST CANCER
Phase: PHASE1 • Sponsor: Affibody • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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New Two-Pronged attack on tough breast cancer shows promise
Disease control Recruiting nowThis study is testing a new treatment strategy for people with stage II-III HER2-positive breast cancer. The goal is to shrink tumors before surgery using a targeted drug combination. If the tumors shrink well, patients continue with the same drugs; if not, they switch to a diffe…
Matched conditions: HER2 + BREAST CANCER
Phase: PHASE2 • Sponsor: Shanghai Jiao Tong University School of Medicine • Aim: Disease control
Last updated Mar 24, 2026 12:01 UTC
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New Two-Pronged attack on advanced breast cancer begins testing
Disease control Recruiting nowThis study is testing a new two-drug combination (HLX22 and HLX87) as the first treatment for people with advanced or spreading HER2-positive breast cancer. It aims to see if this combination can better control the cancer and help patients live longer without their disease gettin…
Matched conditions: HER2 + BREAST CANCER
Phase: PHASE2, PHASE3 • Sponsor: Shanghai Henlius Biotech • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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New hope for Tough-to-Treat breast cancer: two drugs vs. one
Disease control Recruiting nowThis study is testing if combining two drugs, capecitabine and elacestrant, works better than just capecitabine alone for people with advanced, hormone-sensitive breast cancer. It's for patients whose cancer has stopped responding to a common class of prior medications. The main …
Matched conditions: HER2 + BREAST CANCER
Phase: PHASE2 • Sponsor: Kristina A. Fanucci • Aim: Disease control
Last updated Mar 20, 2026 14:48 UTC
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Scientists test 'Switchable' cell therapy to fight advanced breast cancer
Disease control Recruiting nowThis is an early study to test the safety of a new two-part treatment for people with advanced breast cancer that has spread or cannot be removed by surgery. The treatment involves giving patients their own modified immune cells (CLBR001), followed by a biologic drug (ABBV-461) t…
Matched conditions: HER2 + BREAST CANCER
Phase: PHASE1 • Sponsor: Calibr, a division of Scripps Research • Aim: Disease control
Last updated Mar 09, 2026 14:24 UTC
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Major study launches to track 1,000 breast cancer patients
Knowledge-focused Recruiting nowThis study aims to better understand what factors influence survival and treatment success for people with HER2-positive breast cancer. Researchers will follow 1,000 patients with different stages of the disease for five years. The goal is to collect information that may help imp…
Matched conditions: HER2 + BREAST CANCER
Sponsor: Priyanka Sharma • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC
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Blood test could warn of breast Cancer's return
Knowledge-focused Recruiting nowThis study aims to see if a simple blood test can find tiny bits of leftover cancer DNA after treatment. Researchers will track 900 patients with early-stage breast cancer to see if this 'liquid biopsy' can predict if their cancer will come back. The goal is to gather knowledge t…
Matched conditions: HER2 + BREAST CANCER
Sponsor: Tempus AI • Aim: Knowledge-focused
Last updated Mar 20, 2026 14:47 UTC