Can an oral chemo pill boost breast cancer treatment?
NCT ID NCT07739511
First seen Jul 31, 2026 · Last updated Aug 05, 2026 · Updated 2 times
Summary
This trial is testing an oral form of the chemotherapy drug paclitaxel, given alongside standard anti-HER2 therapies (trastuzumab and pertuzumab), for people with HER2-positive breast cancer. The goal is to find the safest and most effective dose of the oral paclitaxel when used before surgery. Participants will receive six cycles of this combination, and the study will monitor for side effects and how well the tumor responds.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Paclitaxel oral solution combined with trastuzumab and pertuzumab (THP regimen)
- What this could lead to
- If successful, this could offer a more convenient oral chemotherapy option for HER2-positive breast cancer, potentially improving treatment response before surgery.
- What could go wrong
- This is an early-phase dose-finding trial with a small number of participants, so the optimal dose and effectiveness are not yet confirmed. Side effects of chemotherapy, such as nerve damage or low blood counts, are possible.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Affiliated Hospital of Guizhou Medical University
RECRUITINGGuiyang, Guizhou, China
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Other studies related to the condition(s) this trial covers.
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