New study tests targeted pill combo for advanced breast cancer in Real-World settings
NCT ID NCT07600164
First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times
Summary
This study will follow 500 people with advanced HER2-positive breast cancer who are receiving pyrotinib (a daily pill) as their first or second treatment. Researchers want to see how well the drug works in real life and whether switching to another targeted therapy (Trastuzumab Rezetecan) after the cancer progresses is safe and effective. The study is not yet recruiting and will run at multiple hospitals in China.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pyrotinib (a targeted cancer pill) and Trastuzumab Rezetecan (an antibody-drug conjugate given by IV)
- What this could lead to
- If successful, this could confirm that pyrotinib works well in everyday practice and that switching to Trastuzumab Rezetecan after progression is a good strategy for advanced HER2+ breast cancer.
- What could go wrong
- This is a real-world study, not a controlled trial, so results may be less reliable. Side effects from the drugs can include diarrhea, nausea, and low blood cell counts. The study hasn't started yet, so outcomes are uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ADVANCED BREAST CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Peking University People's Hospital
RECRUITINGBeijing, Beijing Municipality, 100044, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Two-Step drug combo outsmart advanced HER2-Positive breast cancer?
- Can a pill combo outpace chemotherapy for aggressive breast cancer?
- Can an oral chemo pill boost breast cancer treatment?
- Blood tests could reveal hidden resistance in breast cancer
- Triple threat: three new targeted drugs join forces with immunotherapy to attack Hard-to-Treat breast cancer
- Could a Triple-Drug attack before surgery eliminate more breast cancer in older women?