HER2 + BREAST CANCER
Clinical trials for HER2 + BREAST CANCER explained in plain language.
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New vaccine combo aims to supercharge immune attack on breast cancer
Disease control TerminatedThis study tested whether adding a HER2-targeting vaccine (VRP-HER2) to the immunotherapy drug pembrolizumab could boost the immune system's attack on advanced HER2-positive breast cancer. Eight participants were randomly assigned to receive the vaccine alone, pembrolizumab alone…
Matched conditions: HER2 + BREAST CANCER
Phase: PHASE2 • Sponsor: Herbert Lyerly • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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Experimental combo therapy for advanced breast cancer tested in small early trial
Disease control TerminatedThis early-phase study tested a new treatment for people with advanced breast cancer that had stopped responding to standard therapies. The treatment combined a patient's own engineered immune cells (CLBR001) with an antibody drug (ABBV-461). The study aimed to find the safest do…
Matched conditions: HER2 + BREAST CANCER
Phase: PHASE1 • Sponsor: Calibr, a division of Scripps Research • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Heart-Safe breast cancer treatment? pilot study tests preventive meds
Prevention TerminatedThis pilot study aimed to see if giving heart medications (carvedilol and empagliflozin) to women starting HER2-targeted therapy for breast cancer could prevent heart damage. The study planned to enroll 20-40 participants but was terminated early after enrolling only 7. The goal …
Matched conditions: HER2 + BREAST CANCER
Phase: PHASE2 • Sponsor: Washington University School of Medicine • Aim: Prevention
Last updated Jun 27, 2026 12:34 UTC