New drug may stop aggressive lymphoma relapse after transplant or CAR-T

NCT ID NCT05256641

First seen Nov 11, 2025 · Last updated Jun 10, 2026 · Updated 29 times

Summary

This study tests whether a daily pill called acalabrutinib can help prevent relapse in people with very high-risk large B-cell lymphoma after they have received a stem cell transplant or CAR-T cell therapy. The drug works by blocking a protein that helps cancer cells grow. The trial will enroll 24 adults aged 18-70 and will check how well the drug is tolerated and whether it improves the chance of staying cancer-free for at least one year.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UCLA / Jonsson Comprehensive Cancer Center

    RECRUITING

    Los Angeles, California, 90095, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of California Davis Comprehensive Cancer Center

    RECRUITING

    Sacramento, California, 95817, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Oklahoma

    NOT_YET_RECRUITING

    Oklahoma City, Oklahoma, 73190, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

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