Ohio State University Comprehensive Cancer Center

This early-stage trial tests a vaccine (OSU-2131) designed to protect against Epstein-Barr virus (EBV) and the cancers it can cause, especially in people waiting for an organ transplant. The study includes healthy volunteers and transplant candidates who carry a specific immune g…

This study tests a combination of two drugs, ibrutinib and nivolumab, in adults with classical Hodgkin lymphoma that returned or didn't respond to prior treatment. The goal is to see if the combination can shrink or eliminate cancer. About 18 participants will receive both drugs,…

This study tests whether adding venetoclax to ibrutinib can eliminate genetic mutations that make chronic lymphocytic leukemia (CLL) resistant to ibrutinib. About 28 adults with CLL who have developed these mutations while on ibrutinib will receive the combination for 12 cycles. …

This early-phase trial tests whether adding papaverine, a drug that may make cancer cells more sensitive to radiation, can safely improve treatment for non-small cell lung cancer. About 19 adults with tumors 5 cm or smaller will receive stereotactic body radiation therapy (SBRT) …

This study tests whether giving a single dose of electron beam radiation directly to the tumor cavity during breast-conserving surgery (lumpectomy) and before reconstruction can safely kill leftover cancer cells in women with early-stage breast cancer. About 108 participants with…

This study tests a program to help women in rural Appalachian communities quit smoking. Cigarette smoking raises the risk of cervical cancer, but many rural clinics lack resources to support quitting. The program provides counseling and connects women to services. Researchers wil…

This study looks at whether teaching parents and healthcare providers about the HPV vaccine can increase vaccination rates in girls ages 9 to 17 living in Ohio Appalachia. About 624 parents and providers took part. The goal is to help prevent HPV infections, which can cause certa…

This early-stage study tests whether black raspberry confections can help prevent oral cancer in 67 healthy volunteers. Researchers will measure how the body absorbs berry compounds and how they affect genes linked to cancer and inflammation. Participants follow a berry-restricte…

This study tests whether early visits with a brain health specialist can help people with cancer that has spread to the brain maintain their quality of life after radiation therapy. About 110 adults with stage IV solid tumors and brain metastases will receive neuropsychological c…

This pilot study tested whether a robot-assisted surgical system (da Vinci) can safely perform nipple-sparing mastectomy in 4 women with early-stage breast cancer or those needing preventive breast removal. The goal was to see if the robot could remove all breast tissue through a…

This study tests a web-based portal called YES that helps young breast cancer survivors (ages 15-39) track and manage their symptoms. About 400 women who had early-stage breast cancer within the last 3 years will use the portal or receive standard care. The goal is to see if the …

This study looks at how accurately three different food frequency questionnaires estimate how many fruits and vegetables people eat. Researchers will compare the questionnaire results with actual diet records and with levels of carotenoids (plant nutrients) in the blood and skin.…

This study tests a new nanochip technology to see if it can better monitor how well treatment is working and detect if lymphoma comes back in people with diffuse large B-cell lymphoma. About 73 participants will provide blood samples during their standard chemotherapy. The goal i…

This study looks at whether a 12-week virtual exercise program with group counseling can change gut bacteria and reduce inflammation in smokers at high risk for lung cancer. About 65 people aged 50-77 who smoke or used to smoke will take part. The goal is to see if this approach …

This study looks at how vaping impacts lung function in young adults (ages 21-25) who are either obese or not. Researchers will measure breathing before and after a vaping session, along with vaping habits and cravings. The goal is to understand if obesity makes the lungs more vu…

This study follows 72 women with pelvic cancers (like cervical or rectal) to see how radiation therapy changes their pelvic health and sexual function over two years. Researchers measure physical changes and ask about symptoms like dryness or pain. The goal is to better understan…

This study tests whether a genetic counseling program delivered through a hospital's online patient portal works as well as traditional in-person counseling for women at elevated risk for breast cancer. About 874 women will take part, and researchers will compare how well each gr…

This study aims to find genetic changes that make some families more likely to develop papillary thyroid cancer. Researchers will analyze DNA from 1,200 people, including those with the cancer and their relatives. The goal is to better understand inherited risk, not to test a new…

This pilot study explores whether people with brain metastases can stick to a ketogenic (high-fat, low-carb) diet for 16 weeks while undergoing radiosurgery. Researchers will compare this to a standard healthy diet, tracking diet adherence, blood markers, and quality of life. The…

This study looks at shoulder and arm problems in women with lymph-node positive breast cancer who receive radiation therapy. Researchers want to see how often these problems happen and how severe they are one year after treatment. The goal is to help doctors choose the best radia…

This study looks at how e-cigarettes affect the body by comparing 75 e-cig users with 75 non-users. Researchers measure lung function, airway inflammation, and blood vessel health. The goal is to provide clear evidence to help policymakers create safer tobacco standards.

This study is looking at whether changes in a blood test called tumor fraction can help predict how well immunotherapy works in people with non-small cell lung cancer or kidney cancer. About 100 adults are taking part, and researchers will also look at inflammation, hormone level…

This study looks back at the results of robotic prostate removal surgery in over 1,500 men with prostate cancer. Researchers aim to understand patient traits and how they relate to surgery success, cancer return, and survival. The goal is to improve future treatment decisions.

This study looks at how hormone therapy (anti-androgen treatment) for prostate cancer affects the heart. Researchers will use heart MRIs to measure changes in heart function and muscle in 23 men before and after 4-7 months of treatment. The goal is to better understand the heart …

This study tests whether watching a short video helps people with metastatic cancer understand tumor genomic testing better. About 243 adults with cancer that has spread will watch the video and answer questions before and after. The goal is to see if the video improves knowledge…

This study looks at two methods of collecting tissue samples from lymph nodes in people with suspected lung cancer. During a standard procedure called EBUS-TBNA, doctors sometimes use suction to help gather more material. The trial will compare samples taken with and without suct…

This study looks for early signs of heart injury in people receiving radiation therapy for lung or esophageal cancer. Researchers use heart scans and blood tests to detect changes during or shortly after treatment. The goal is to identify patients at risk for heart problems and i…