Ohio State University Comprehensive Cancer Center

This early-stage trial tests a vaccine called OSU-2131, designed to help the immune system fight Epstein-Barr virus (EBV). EBV can cause cancers in people who have weakened immune systems, such as those awaiting organ transplants. The study includes healthy volunteers and transpl…

This early-phase trial tests whether injecting special immune cells (natural killer cells) directly into skin cancer tumors can safely kill cancer cells. The study compares two types of donor NK cells—standard ones and ones engineered to be more potent—in 40 patients with basal o…

This trial tests a sticky patch that releases fenretinide, a vitamin A derivative, directly onto precancerous spots inside the mouth. The goal is to see if the patch can shrink these lesions, reduce their severity under the microscope, and lower genetic changes linked to oral can…

This study tests whether giving a single dose of radiation directly to the tumor site during breast-conserving surgery (lumpectomy) and before reconstruction is safe and effective for women with early-stage breast cancer. About 108 participants with stage I-II breast cancer will …

This early-phase trial is testing whether a ketogenic diet (low carbs, high fat) can safely help immunotherapy drugs work better in people with advanced melanoma or kidney cancer. About 60 participants will follow the diet while receiving standard immunotherapy. The main goals ar…

This study tests whether combining ibrutinib and nivolumab can help people with classical Hodgkin lymphoma that has returned or not responded to prior treatment. About 18 adults will receive both drugs to see if the cancer shrinks or disappears. The goal is to improve disease con…

This phase 2 trial is testing whether adding venetoclax to ibrutinib can eliminate resistance mutations in people with chronic lymphocytic leukemia (CLL) who have developed resistance to ibrutinib alone. The study enrolls 28 participants who are already taking ibrutinib and have …

This early-phase trial tests whether adding a drug called papaverine to precise, high-dose radiation (SBRT) can help control non-small cell lung cancer. About 19 patients with a single lung tumor will receive both treatments. The main goal is to find the safest dose and see if th…

This pilot study tested whether a robot-assisted surgical technique (using the daVinci system) can safely remove breast tissue while sparing the nipple in people with early-stage breast cancer or those needing preventive mastectomy. Only 4 participants were enrolled, and the stud…

This study tests a program to help women in rural Appalachian communities quit smoking. Cigarette smoking is a major cause of cervical cancer, but rural clinics often lack resources to support quitting. The program trains healthcare providers to identify smokers, offer advice, an…

This trial tests whether a program that combines educational materials with electronic health record reminders can increase HPV vaccination rates among children and young adults aged 11–26 in four Appalachian states. The goal is to improve vaccine uptake and ultimately prevent ce…

This study tests whether a patient navigator—a guide who helps women understand their options—can improve how high-risk women manage their breast cancer risk. About 75 women with a family history of breast cancer but no personal diagnosis will receive support to make informed cho…

This study tested whether an educational program for parents and healthcare providers could increase HPV vaccination rates among girls aged 9 to 17 in Ohio Appalachia. Over 600 parents and providers took part. The goal was to see if teaching about the vaccine leads to more girls …

This study tests whether training the muscles you use to breathe can improve how long obese breast cancer survivors can exercise. Researchers will compare breathing exercises plus aerobic exercise to aerobic exercise alone in 78 women who finished treatment. The goal is to see if…

This study tests whether a phone app can help people with chest-area cancers and their caregivers report symptoms early and request palliative care on their own. The goal is to improve quality of life by managing pain and stress sooner. About 157 participants will use the app to …

This study tests a telemedicine program called FOCUS that helps advanced cancer patients manage common symptoms like trouble sleeping, worry, tiredness, and low mood. The program uses counseling techniques delivered through a phone app. Researchers will enroll 120 adults with adv…

This study compares the effects of soy soft pretzels and wheat pretzels on inflammation in 30 men with obesity. Researchers want to see if the natural chemicals in soy can reduce chronic inflammation, which is linked to health problems like cancer. Participants will eat either so…

This study tests a web-based portal called YES (Young, Empowered & Strong) designed to help adolescent and young adult breast cancer survivors monitor and manage their symptoms. Researchers will compare the quality of life of 400 women who use the portal to those receiving standa…

This study looks at whether a ketogenic (high-fat, low-carb) diet is practical and beneficial for 24 adults with brain metastases who are scheduled for radiosurgery. Participants will follow either a ketogenic diet or a standard healthy diet for 16 weeks. Researchers will track d…

This study tests whether early visits with a brain health specialist can help people with cancer that has spread to the brain maintain their quality of life after radiation therapy. About 110 adults with solid tumors and brain metastases will receive neuropsychological care along…

This study looks at how synthetic cooling additives (like WS-3 and WS-23) in e-cigarettes change how young adults perceive and use them. About 158 current e-cigarette users aged 21-29 will try different flavored e-liquids and report their satisfaction, sensory experiences, and pu…

This study follows 72 women with pelvic cancers (anal, cervical, endometrial, rectal, vaginal, or vulvar) who are receiving radiation therapy. Researchers will use pelvic exams and surveys to measure changes in vaginal health, sexual function, and quality of life over two years. …

This study tests whether watching a short video can improve understanding of tumor genomic testing in 243 adults with metastatic cancer. Participants watch the video and then answer questions to measure their knowledge. The goal is to see if this simple tool helps patients better…

This study looks at how e-cigarette use impacts the body by comparing 75 e-cig users with 75 non-users. Participants undergo tests like breath analysis, lung function tests, and blood collection. The goal is to provide data that could help shape future tobacco regulations.

This study looks at how hormone therapy (anti-androgen treatment) for prostate cancer affects the heart. Researchers will use heart MRI scans before and after 4-7 months of treatment in 23 men. The goal is to understand changes in heart function, not to treat the cancer itself.

This study follows 61 women with lymph-node positive breast cancer to see how two types of radiation therapy affect shoulder and arm function one year after treatment. Participants receive either intensity-modulated radiation therapy (IMRT) or 3D conformal radiation therapy (3DCR…

This study looks at whether a 12-week virtual exercise program with group counseling can reduce inflammation and improve gut bacteria in smokers at high risk for lung cancer. About 65 participants aged 50-77 who smoke or used to smoke will take part. The goal is to see if this ap…

This study looks for early signs of heart damage in people getting radiation therapy for lung or esophageal cancer. Researchers use heart scans and blood tests to see if changes happen during or shortly after treatment. The goal is to find patients at risk and help make future ca…

This study reviews the results of robotic prostate surgery in over 1,500 men with prostate cancer. Researchers are collecting data on patient characteristics and surgical outcomes, including survival and cancer recurrence. The goal is to understand how well the surgery works and …

This pilot study is testing a nanochip (ILN biochip) to see if it can monitor how well treatment is working and detect relapse in people with diffuse large B-cell lymphoma. About 73 patients will provide blood samples for the chip to analyze genetic markers. The goal is to find o…

This study tests whether a genetic counseling video delivered through a patient portal works as well as traditional in-person genetic counseling for women at elevated breast cancer risk. About 874 women aged 30-64 will be randomly assigned to either the video or standard counseli…

This study is looking at whether changes in a blood test called tumor fraction can help predict how well immunotherapy works in people with non-small cell lung cancer or kidney cancer. About 100 adults will have blood samples taken before and during their standard treatment. The …

This study tests how well three different food frequency questionnaires estimate how many fruits and vegetables people eat. Researchers will compare the questionnaire results to actual diet records and blood and skin tests for carotenoids—natural pigments found in plants. The goa…

This study looks at how vaping impacts lung function in young adults ages 21-25, comparing those with and without obesity. Researchers measure breathing before and after a vaping session to see immediate effects. The goal is to understand risks, not to test a treatment.

This study aims to find the genetic changes that make some families more likely to develop papillary thyroid cancer. Researchers will analyze DNA from 1,200 people who either have this cancer and have at least three affected relatives, or are family members of such patients. The …