Cooling agents in vapes: do they make them more addictive?
NCT ID NCT06208202
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how synthetic cooling additives (like WS-3 and WS-23) in e-cigarettes change how young adults perceive and use them. About 158 current e-cigarette users aged 21-29 will try different flavored e-liquids and report their satisfaction, sensory experiences, and puffing behavior. Researchers will also measure toxicant levels in the vapor. The goal is to understand if these additives make vaping more appealing or risky.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
flavored e-cigarettes with synthetic cooling agents (WS-3, WS-23)
What this could lead to
If successful, this could help regulators understand how cooling additives make e-cigarettes more appealing or harmful, informing future policies.
What could go wrong
This is an observational behavioral study with only 158 participants, so results may not apply to all users. It measures perceptions and exposure, not health outcomes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States