Cooling agents in vapes: do they make them more addictive?

NCT ID NCT06208202

Ongoing Knowledge-focused Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how synthetic cooling additives (like WS-3 and WS-23) in e-cigarettes change how young adults perceive and use them. About 158 current e-cigarette users aged 21-29 will try different flavored e-liquids and report their satisfaction, sensory experiences, and puffing behavior. Researchers will also measure toxicant levels in the vapor. The goal is to understand if these additives make vaping more appealing or risky.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: flavored e-cigarettes with synthetic cooling agents (WS-3, WS-23)
What this could lead to: If successful, this could help regulators understand how cooling additives make e-cigarettes more appealing or harmful, informing future policies.
What could go wrong: This is an observational behavioral study with only 158 participants, so results may not apply to all users. It measures perceptions and exposure, not health outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nicotine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ABUSE TOBACCO EXPOSURE

Contacts and locations

Locations

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

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