Ohio State University Comprehensive Cancer Center

This early-phase study tested adding the drug romidepsin to standard chemotherapy before and after a stem cell transplant in 23 adults with certain T-cell cancers (like lymphoma or leukemia). The main goals were to find the safest dose and see if the combination helps control the…

This study tested a combination of two hormone-blocking drugs, fulvestrant and palbociclib, in 14 elderly patients with hormone-sensitive breast cancer who either had inoperable tumors or were too frail for surgery. The goal was to see if this drug pair could control the cancer f…

This study looked at whether switching from regular cigarettes to either low or high wattage e-cigarettes changes smoking habits and reduces exposure to harmful chemicals. 372 adult smokers who were not planning to quit took part. Researchers measured how many people stopped smok…

This study tested a combination of two drugs, MOR00208 and lenalidomide, in 41 people with chronic lymphocytic leukemia (CLL) or related blood cancers. The goal was to see if the combination could shrink or control the cancer in patients who had not responded to prior treatments …

This study tested whether small, adhesive sensors placed on the skin can detect early signs of lymphedema, a painful arm swelling that can happen after cancer treatment. Researchers compared readings from 76 people with and without lymphedema to see if the sensors could tell the …

This study tested whether mailing HPV self-test kits to women in Appalachia who are behind on screening could increase cervical cancer detection. Over 800 women who hadn't had a Pap test in 3+ years or an HPV test in 5+ years took part. The goal was to see if self-testing at home…

This study tested whether a special diet that keeps insulin levels low could reduce breast cancer risk in women already at high risk. The diet is rich in fruits, vegetables, whole grains, and plant proteins, and low in animal protein and unhealthy fats. The main goal was to see i…

This study tested whether sending educational text messages about tobacco risks could help LGBTQ+ young adults quit smoking or vaping. Researchers enrolled 292 participants aged 18-35 who identified as LGBTQ+ and used tobacco products. Participants received different types of tex…

This study tested whether an online program that provides diet advice and resistance training exercises can help older adults (65+) who have finished treatment for breast, colorectal, or prostate cancer. The goal was to see if the program could improve physical function, diet, an…

This study tested a supportive care program for adults aged 60 and older with advanced lung cancer. The program combined physical therapy and relaxation exercises to help improve physical function and emotional well-being during cancer treatment. About 100 participants took part …

This study tested a new approach for older patients with early-stage hormone-positive breast cancer: giving a high dose of focused radiation before surgery instead of after. The goal was to shrink the tumor and reduce damage to healthy tissue. Twenty-two patients participated to …

This study looked at whether group dance classes can help breast cancer survivors who have nerve damage (neuropathy) from chemotherapy. 52 survivors took part. The goal was to see if dancing improves balance and quality of life. The approach uses fun, social exercise as a drug-fr…

This study tested an online Tai Chi program to help cancer survivors stop smoking. Sixty-eight cancer survivors who smoked took part in the 8-week program, which involved slow movements, meditation, and breathing exercises. The goal was to see if Tai Chi could help them quit or r…

This study analyzed blood, urine, and tissue samples from 273 adults with brain or lung cancer who were receiving radiation therapy. The goal was to find biological markers that could predict which patients are more likely to develop serious side effects from radiation and how we…

This study looked at how genetic differences affect the body's ability to clear high-dose methotrexate in patients with diffuse large B-cell lymphoma. Researchers analyzed DNA from 20 participants to find gene variations linked to slower drug clearance. The goal was to better und…

This study looked at 182 older adults with blood cancer or lung cancer to see if a special calculator could predict who would have severe side effects from chemotherapy. Researchers measured patients' fitness before and after treatment. The goal is to help doctors choose safer tr…

This study examined how nicotine pouches, a new smokeless tobacco product, are used by adults in rural Ohio and Appalachia. Researchers wanted to understand their appeal and potential health effects. The study involved 71 daily smokeless tobacco users who were asked to try nicoti…

This study examined lung cells from 66 smokers to see how switching to e-cigarettes or nicotine replacement therapy changes the lungs. Researchers used a camera tube (bronchoscopy) to collect fluid and cell samples. The goal was to find early signs of cancer risk by measuring inf…

This study looked at whether synthetic cooling agents, used as a replacement for menthol in cigarettes, change how appealing or addictive the cigarettes are. 34 young adult smokers tested three types of cigarettes: menthol, non-menthol, and those with synthetic coolants. Research…

This study tested a mobile 3D scanning app to measure swelling (lymphedema) in the head and neck. Researchers wanted to see if the app could accurately track changes in swelling over time. 13 patients with head and neck lymphedema were scanned multiple times. The goal was to impr…

This study looked at how young adults (ages 21-34) who vape regularly perceive and react to e-cigarettes containing a new nicotine-like substance called metatine. Researchers measured things like how the body processes the substance, puffing behavior, and sensory experiences. The…

This study tested a personalized geriatric optimization plan (GO!) in 30 patients aged 60 and older who were getting a stem cell transplant for blood cancers or bone marrow failure. The plan included tailored changes to diet, sleep, activity, and medications. The goal was to see …

This study tested whether a short video sent by text message could help people with BRCA gene mutations talk to their relatives about getting tested. 58 participants who tested positive for BRCA1 or BRCA2 took part. The goal was to see if the video made it easier to share importa…

This study surveyed 109 men with prostate cancer and women with breast cancer to see how often they used complementary and alternative medicines (like supplements) during radiation therapy. Participants filled out surveys at three different times to track any changes in their use…

This study screened over 1,000 women with endometrial cancer for DNA repair problems and Lynch syndrome, an inherited condition that raises cancer risk. By analyzing tumor DNA, researchers aimed to personalize treatment and identify at-risk relatives. The goal was to improve surv…

This study tested a training program for community healthcare providers to improve their knowledge and skills in caring for cancer survivors. Twenty-eight providers from five Ohio hospitals participated. The program aimed to help doctors better understand survivors' long-term hea…