Ohio State University Comprehensive Cancer Center

This study looked at whether switching from regular cigarettes to either low or high wattage e-cigarettes changes smoking behavior and reduces exposure to harmful chemicals. 372 daily smokers who were not planning to quit were given e-cigarettes to use freely for 12 weeks, then c…

This study tested a personalized geriatric optimization plan (GO!) in 30 adults aged 60 and older who were getting a donor stem cell transplant for blood cancers or bone marrow failure. The plan included tailored advice on diet, sleep, activity, and medications to improve physica…

This completed trial tested an online Tai Chi program to help cancer survivors stop smoking. Sixty-eight participants practiced slow movements and breathing exercises over 8 weeks, with their progress tracked via carbon monoxide tests and surveys. The goal was to see if this gent…

This phase II trial tested a combination of hormone therapy drugs (fulvestrant or an aromatase inhibitor) plus palbociclib in 14 elderly patients with hormone-responsive breast cancer who either had inoperable tumors or were too frail for surgery. The goal was to see if this drug…

This phase II trial tested a combination of two drugs—MOR00208 (an antibody that targets cancer cells) and lenalidomide (which boosts the immune system)—in 41 people with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or prolymphocytic leukemia (PLL). Some …

This pilot study tested whether giving a high dose of focused radiation (APBI) to the tumor before surgery is feasible for older women with early-stage, hormone-sensitive breast cancer. Twenty-two participants received radiation followed by a lumpectomy. The goal was to see if th…

This early-phase trial tested whether adding the drug romidepsin before and after a stem cell transplant could help control T-cell cancers like lymphoma and leukemia. Twenty-three patients received romidepsin along with standard chemotherapy, followed by a donor stem cell transpl…

This study tested new adhesive sensors that stick to the skin to see if they can detect early signs of lymphedema, a painful arm swelling that can happen after cancer treatment. Researchers compared readings from 76 people with and without lymphedema. The goal is to create a simp…

This study tested whether offering at-home HPV self-testing kits can increase cervical cancer screening among women in Appalachia who are overdue for screening. Over 800 women from participating clinics were given either usual care or a self-testing kit along with information and…

This early-stage trial tested whether black raspberry confections (like lozenges) could help prevent oral cancer. Sixty-seven healthy volunteers ate different versions of the confection to see which was most acceptable and how it affected genes and chemicals linked to cancer. The…

This pilot study tested whether a diet designed to lower insulin levels could reduce breast cancer risk in 34 high-risk women. The diet is rich in fruits, vegetables, whole grains, and plant protein, and low in animal protein and fat. The main goal was to see if women could stick…

This study looked at whether a group resistance exercise program could help head and neck cancer patients maintain muscle and quality of life during chemoradiation. Twenty adults with advanced head and neck cancer took part in supervised strength training sessions. Researchers me…

This study tested whether an online program combining nutrition counseling and resistance training could improve physical function in older adults (65+) who finished treatment for breast, colorectal, or prostate cancer. 75 participants received virtual sessions with dietitians an…

This study tested a supportive care program for adults aged 60 and older with advanced lung cancer. The program combined physical therapy and relaxation exercises to help improve physical function and emotional wellbeing. Researchers measured how well participants stuck with the …

This study tested whether group dance classes can improve balance and motivation in breast cancer survivors who have nerve damage from chemotherapy. Fifty-two survivors participated in either dance-based exercise or standard exercise for several weeks. The goal was to see if danc…

This study looks at whether using suction during a lung biopsy (EBUS-TBNA) helps get better tissue samples from people with suspected lung cancer that has spread to lymph nodes. Researchers will compare samples taken with and without suction to see which method gives more materia…

This study examined the vaginal microbiome—the community of bacteria and other microbes—in 35 women with breast cancer who were receiving hormone therapy. The goal was to see if certain bacteria are linked to vaginal dryness and sexual health. Researchers collected vaginal swabs …

This study looked at whether synthetic cooling agents, which replace banned menthol in cigarettes, change how appealing or addictive cigarettes are. Researchers had 34 young adult smokers try these new cigarettes and measured their smoking behavior and preferences. The goal was t…

This study looked at 58 young adults aged 18-29 who regularly use e-cigarettes. Researchers measured heavy metals in their saliva and tested their lung function before and after a 30-minute vaping session. The goal was to understand how vaping exposes the body to metals and affec…

This early-phase trial studied how compounds from black raspberries are absorbed and processed in 60 men with prostate cancer who were scheduled for surgery. Participants ate a black raspberry confection and followed a special diet before surgery. The goal was not to treat cancer…

This study examined how nicotine pouches (like ZYN and Rogue) affect people who use smokeless tobacco in rural Ohio and Appalachia. Researchers measured nicotine levels in the blood and asked participants about their intentions to use these products. The goal was to understand wh…

This early-phase study looked at how e-cigarettes affect lung cells and cancer-related markers. Researchers used a bronchoscope to collect lung samples from 66 smokers who either continued smoking, switched to e-cigarettes (with or without nicotine), or used nicotine replacement …

This study looked at 182 older adults with blood cancer or lung cancer to see if a special calculator could predict who would have severe side effects from chemotherapy. Researchers measured patients' fitness before and after treatment to better understand how well they could han…

This study analyzed blood, urine, and tissue samples from 273 adults with brain or lung cancer who were receiving radiation therapy. The goal was to find biological markers that could predict which patients are more likely to develop serious side effects from radiation, such as l…

This study tested a mobile 3D scanning app to measure swelling (lymphedema) in the head and neck area. Lymphedema is a buildup of fluid that causes swelling, often after cancer treatment. The goal was to see if this simple scanning method could accurately measure swelling and tra…

This study looked at whether specially designed text messages about the risks of using multiple tobacco products can help LGBTQ+ young adults (ages 18-35) quit or cut back. The messages were tailored to their community and compared to general health messages. The goal was to see …

This study tested whether a short video sent by text message could help people with BRCA gene mutations encourage their relatives to get tested. Fifty-eight participants completed the trial. The goal was to see if the video made it easier to share important health information wit…

This study examined how genetic variations influence the body's ability to clear high-dose methotrexate in 20 adults with diffuse large B-cell lymphoma or central nervous system lymphoma. Researchers looked for specific gene changes linked to slower drug removal. The goal was to …

This study surveyed 109 men with prostate cancer and women with breast cancer who were starting radiation therapy. Researchers asked about their use of complementary and alternative medicines (CAM), such as nutritional supplements, at three different times to see if their habits …

This completed study looked at how 53 young adults (ages 21-34) who regularly vape perceive and react to e-cigarettes containing a new substance called metatine (6-methyl nicotine). Researchers measured how the body processes metatine, puffing behavior, sensory experiences, and a…

This study tested a training program for community healthcare providers to improve their knowledge and skills in caring for cancer survivors. Twenty-eight providers from five Ohio hospitals participated in virtual sessions covering topics like long-term side effects, health promo…

This study tested over 1,000 women with endometrial cancer for DNA repair problems that can be inherited (Lynch syndrome). By analyzing tumor DNA, researchers aimed to personalize cancer treatment and identify family members who might also be at risk. The goal was to improve care…