Could a short course of radiation before surgery spare more breast tissue?
NCT ID NCT02186470
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This pilot study tested whether giving a high dose of focused radiation (APBI) to the tumor before surgery is feasible for older women with early-stage, hormone-sensitive breast cancer. Twenty-two participants received radiation followed by a lumpectomy. The goal was to see if this approach could shrink the tumor and reduce the amount of healthy tissue removed, while keeping side effects manageable.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
accelerated partial breast irradiation (APBI)
What this could lead to
If successful, this approach could allow some patients to have less extensive surgery and better cosmetic outcomes after breast cancer treatment.
What could go wrong
This is a very small, early feasibility study with only 22 participants, so results may not apply to all patients. Radiation before surgery can cause side effects like skin reactions or changes in healing.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States