Could freezing replace the scalpel for some breast cancers?

NCT ID NCT02200705

Completed Disease control Sponsor: IceCure Medical Ltd. Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This trial tests whether freezing a small, low-risk breast tumor (cryoablation) can control the cancer as well as surgical removal. About 200 women with invasive ductal breast cancer tumors 1.5 cm or smaller will receive cryoablation and be followed for 5 years to check for local recurrence and quality of life. The goal is to see if a needle-based freezing procedure can be a less invasive alternative to lumpectomy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cryoablation (freezing) device
What this could lead to: If successful, this could offer a non-surgical treatment option for certain small, early-stage breast cancers, potentially reducing recovery time and scarring.
What could go wrong: This is a single-arm study without a surgery comparison group, so it may not prove cryoablation is as effective as lumpectomy. There is a risk of incomplete tumor freezing or later recurrence.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm invasive ductal breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

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Locations

Breast Specialty care/ Presbyterian Hospital

Albuquerque, New Mexico, 87114, United States
BreastLink

Santa Ana, California, 92705, United States
Bridgeport Hospital, Yale Medical School

Trumbull, Connecticut, 06611, United States
CentraState Medical Center

Freehold, New Jersey, 07728, United States
Cincinnati Breast Surgeons Inc.

Cincinnati, Ohio, 45227, United States
Columbia University/ NY Presbyterian hospital

New York, New York, 10032, United States
Complete Breast Care

Plano, Texas, 75075, United States
Comprehensive Breast Care

Troy, Michigan, 48085, United States
Dalton Surgical Group

Dalton, Georgia, 30720, United States
Indiana University

Indianapolis, Indiana, 46202-5116, United States
Ironwood Cancer & Research Centers

Glendale, Arizona, 85306, United States
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Montefiore Medical Center

New York, New York, 10467, United States
Mount Sinai Beth Israel

New York, New York, 10011, United States
Regional Medical Imaging

Flint, Michigan, 48507, United States
Thomas Jefferson University hospital

Philadelphia, Pennsylvania, 19107, United States
University hospitals cleveland medical center

Cleveland, Ohio, 44106, United States
Weill Cornell Medical College

New York, New York, 10065, United States
West Clinic

Germantown, Tennessee, 38138, United States

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