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Universal DNA screening in endometrial cancer reveals hidden genetic risks

NCT ID NCT03460483

Completed Knowledge-focused Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested over 1,000 women with endometrial cancer for DNA repair problems that can be inherited (Lynch syndrome). By analyzing tumor DNA, researchers aimed to personalize cancer treatment and identify family members who might also be at risk. The goal was to improve care and outcomes for patients and their relatives.

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Conditions

The condition(s) this trial relates to.

Colorectal Neoplasms, Hereditary Nonpolyposis endometrial carcinoma endometrium adenocarcinoma endometrium neoplasm Lynch syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL ADENOCARCINOMA ENDOMETRIAL CARCINOMA LYNCH SYNDROME RELATIVES

Contacts and locations

Locations

  • Aultman Health Foundation

    Canton, Ohio, 44710, United States

  • Mercy Health - St. Vincent Medical Center

    Toledo, Ohio, 43608, United States

  • MetroHealth Medical Center

    Cleveland, Ohio, 44109, United States

  • Ohio Health

    Columbus, Ohio, 43214, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • Summa Akron City Hospital/Cooper Cancer Center

    Akron, Ohio, 44304, United States

  • TriHealth Cancer Institute-Westside

    Cincinnati, Ohio, 45245, United States

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of Cincinnati

    Cincinnati, Ohio, 45219, United States

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