ENDOMETRIAL CARCINOMA

This study tests a new drug called CR-001 in adults with advanced solid tumors that have spread. The goal is to find the safest dose and see if it can shrink tumors. About 290 people will take part in this early-phase trial.

This phase 3 trial tests whether adding targeted drugs (trastuzumab and pertuzumab) to standard chemotherapy can better shrink tumors in people with HER2-positive endometrial cancer. The study plans to enroll 360 participants with various stages of the disease. However, the trial…

This phase 3 trial is testing whether a targeted drug (trastuzumab deruxtecan) combined with immunotherapy (rilvegostomig or pembrolizumab) works better than standard chemotherapy plus pembrolizumab for people with advanced or recurrent endometrial cancer that has a specific prot…

This early-stage trial tests two experimental mRNA therapies (mRNA-4106 and mRNA-4200) in 42 people with advanced solid tumors like melanoma, lung, or liver cancer. Some participants receive the mRNA therapy alone, others get it combined with the immunotherapy drug pembrolizumab.…

This early-phase study tests a new drug called HWK-016 in people with advanced ovarian or endometrial cancers that have not responded to other treatments. The drug is designed to deliver a toxic payload directly to cancer cells that carry a specific marker (MUC16). The main goals…

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This early-stage study tests a new drug called HWK-007 in people with advanced solid tumors, including certain ovarian, endometrial, and lung cancers. The drug is designed to target a protein (PTK7) found on cancer cells and deliver a chemotherapy-like payload directly to them. T…

This Phase 3 trial is testing a new drug called puxitatug samrotecan against standard chemotherapy in 800 people with advanced endometrial cancer that has worsened after platinum-based chemo and immunotherapy. The goal is to see if the new drug can delay cancer growth or improve …

This phase 3 trial tests whether the targeted drug trastuzumab deruxtecan (T-DXd) works better than standard chemotherapy after surgery for HER2-positive endometrial cancer. About 710 adults with early-stage or locally advanced disease will be randomly assigned to receive T-DXd o…

This early-phase trial is testing a new drug, FOG-001, in about 595 people with advanced or metastatic solid tumors, including colorectal, prostate, and liver cancers. The drug is given alone or with other cancer treatments to see if it is safe and shrinks tumors. The study is cu…

This study tests whether a program of exercise and nutrition counseling helps women with ovarian or endometrial cancer stick with their chemotherapy plan. About 200 women who are about to start chemotherapy will be randomly assigned to either receive weekly coaching sessions on p…

This study tests a new drug called BNT329 in people with advanced solid tumors that have a specific marker (CA19-9). The main goals are to check safety and find the best dose. About 245 participants will take part. The drug works by targeting cancer cells and may help control tum…

This study tests an experimental drug called Tulmimetostat (DZR123) in people with advanced solid tumors or lymphomas that have not improved with standard treatments. The drug is taken as a daily pill, either alone or combined with another drug (enzalutamide) for certain prostate…

This study tests if the drug elacestrant, alone or with abemaciclib, can shrink or control advanced or recurrent ER+ endometrial cancer. About 75 adults who have already had chemotherapy and immunotherapy will take part. The goal is to see how well the treatment works and if it i…

This large Phase 3 study tests a new drug called mocertatug rezetecan (Mo-Rez) against standard chemotherapy for people with endometrial cancer that has progressed after platinum-based chemo and immunotherapy. About 600 participants will be randomly assigned to receive either Mo-…

This study tests a drug called enfortumab vedotin in up to 12 people with advanced endometrial (uterine) cancer that has worsened after standard treatments like immunotherapy. The drug works by targeting a protein on cancer cells to kill them. Researchers will measure how many pa…

This early-phase trial is testing the safety and best dose of two drugs, M1774 and ZEN-3694, given together to patients with recurrent ovarian or endometrial cancer. The drugs work by blocking enzymes that cancer cells need to grow. The study aims to find a dose that is safe and …

This early-phase study tests whether a short course of radiation (1 week instead of the usual 5) combined with standard chemotherapy (carboplatin and paclitaxel) is practical for people with stage III endometrial cancer. The trial will enroll 28 participants and aims to see if mo…

This study tests a new treatment for people with solid tumors that have come back or not responded to standard care. The treatment uses a patient's own immune cells (T-cells) that are genetically modified in a lab to recognize and attack a protein called PRAME found on cancer cel…

This study tests a drug called tegavivint in children, teens, and young adults whose solid tumors have come back or stopped responding to treatment. The goal is to find the safest dose and see if it can shrink tumors by blocking a key growth signal inside cancer cells. About 147 …

This study is for people with endometrial cancer that has come back or spread to a few other spots. It tests a new drug called cadonilimab given together with standard chemotherapy and radiation. The goal is to see if this combination can shrink tumors and help people live longer…

This study tests a personalized vaccine plus three other drugs in 60 adults with advanced HER2-positive endometrial cancer that returned after treatment. The vaccine is made from each patient's own blood cells and targets the HER2 protein. The goal is to see if this combination c…

This early-phase study tests an experimental therapy called FT836, a ready-made CAR T-cell treatment, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers that have not responded to prior treatments. The main goals are…

This study aims to improve fertility-sparing treatment for young women (ages 18-45) with endometrial cancer by tailoring therapy to the tumor's genetic profile. Participants will receive either hormone therapy (progestins) or a combination with an immunotherapy drug (sintilimab),…

This phase 2 trial tests a personalized cell therapy called lifileucel (TIL) in 60 people with advanced endometrial cancer that has been treated before. Doctors take a sample of the patient's tumor, grow immune cells from it in a lab, and then infuse them back after a short cours…

This study is testing a new robotic system, called da Vinci SP, for surgery to stage and treat endometrial cancer. The surgery involves removing the uterus, ovaries, and fallopian tubes, and checking nearby lymph nodes. Researchers want to see if this robot is safe and effective …

This study explores whether an artificial intelligence (AI) program can accurately identify endometrial cancer or precancerous changes by analyzing standard transvaginal ultrasound images. Researchers will compare the AI's predictions with results from endometrial biopsies in 300…

This trial tests a blended e-health program designed to help women with breast or gynecologic cancer cope with fear of their cancer returning or worsening. The program combines remote group sessions with online modules that teach skills to manage unhelpful thoughts and promote he…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if home treatment is preferred and improves satisfaction, while also checking safety. Participants will receive their usual cance…

This study tests a new way to deliver radiation therapy for endometrial cancer using daily MRI scans to guide the beam. The goal is to give a higher dose of radiation to the tumor while sparing nearby organs like the bowel and bladder. Thirty participants will receive 15 sessions…

This study tests whether a personalized physical activity program using a wearable device (like a Fitbit) can help people with ovarian or endometrial cancer exercise more and improve their quality of life. About 120 participants will either receive tailored activity goals and fee…

This study looks at how people with endometrial cancer find medical information and how satisfied they are with it. Researchers will also ask patients if they'd be interested in using an AI-powered educational tool. The goal is to understand current needs and see if AI could help…

This study looks at whether older adults with gynecologic cancer are willing to complete physical and cognitive tests before and after treatment. Researchers will also take small muscle and blood samples to study how cell energy relates to resilience. The goal is to see if this k…

This study is testing a computer model called ENDORISK that helps doctors predict whether endometrial cancer has spread to lymph nodes. About 735 patients with early-stage endometrial cancer will use the model to guide decisions about lymph node surgery. The goal is to see if the…

This study looks at whether giving chemotherapy before surgery helps older adults (over 55) with advanced ovarian or endometrial cancer become fitter for their operation. Researchers will measure changes in frailty using a special score from medical records. The goal is to see if…

This study asks Black women aged 45 and older how they feel about using a vaginal fluid sample to test for DNA markers of endometrial cancer. The goal is to understand if women would accept this as a screening method. No treatment is given—just a 30-minute virtual interview to ga…

This study investigates why some advanced or recurrent endometrial cancers respond to immunotherapy while others do not. Researchers will collect tumor samples from 510 patients before they start immunotherapy and use lab-grown tumor models to study molecular and genetic features…

This study looks at two surgical methods for early-stage endometrial cancer: laparoscopy (keyhole surgery) and laparotomy (open surgery). It aims to see which one helps patients recover faster, especially in places with limited medical resources. About 48 women will take part, an…

This trial is testing whether using a uterine manipulator during minimally invasive hysterectomy for endometrial cancer affects the chance of cancer coming back. About 1,030 women with early-stage endometrial cancer will be randomly assigned to have surgery with or without the de…

This study surveys about 264 Italian hospitals that treat endometrial cancer to find out how often they use POLE testing. POLE testing helps doctors know which patients have a very low risk of cancer returning and may not need extra treatment. The goal is to understand current pr…

This study looks at the genetics of high-risk endometrial cancer to find out why it sometimes returns after treatment. About 100 adults having surgery at Mayo Clinic will provide tissue and blood samples. Researchers will analyze these samples to build a databank for future studi…

This study at Mayo Clinic is testing new AI-based image processing techniques (AIR Recon DL and Sonic DL) to see if they can make MRI scans faster and clearer for detecting pelvic abnormalities like endometrial and prostate cancer. Researchers will compare the new methods to stan…

This study tests whether a special ultrasound can measure changes in vaginal tissue caused by radiation therapy for endometrial cancer. Ten participants will have ultrasound scans before and after treatment to see if the method works. The goal is to better understand and monitor …

This study looks at DNA methylation patterns in brain, thyroid, and endometrial tumors. Researchers aim to better classify these cancers and find new markers for early diagnosis. The study will involve 180 participants and uses existing tumor samples.