ENDOMETRIAL CARCINOMA

This study tests a personalized vaccine plus two approved drugs and an immune booster in people with advanced HER2-positive endometrial cancer. The vaccine is made from each participant's own blood cells and aims to help the immune system attack cancer. The goal is to see if this…

This early-phase study tests whether giving radiation over just one week (instead of the usual five) alongside standard chemotherapy is practical for people with stage III endometrial cancer. About 28 participants who have already had surgery will receive the combined treatment. …

This early-phase study tests a combination of two experimental drugs (M1774 and ZEN-3694) in people whose ovarian or endometrial cancer has returned after previous treatment. The goal is to find the safest dose and see how well the drugs work together to stop cancer cell growth. …

This study tests a new drug, FOG-001, in about 595 people with advanced solid tumors that have not responded to other treatments. The goal is to see if FOG-001 is safe and can shrink tumors or slow their growth. The trial focuses on several cancer types, including colorectal, pro…

This early-stage study tests a new cancer treatment called FT836, a ready-made immune cell therapy, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers. The treatment is given alone or with chemotherapy and/or antibod…

This study tests a drug called tegavivint in children, teens, and young adults (ages 1 to 30) whose solid tumors have returned or are not responding to standard treatments. The drug works by blocking a key signal that tells cancer cells to grow. The trial aims to find the safest …

This large, late-stage trial is testing whether adding newer, faster-to-administer targeted drugs to standard chemotherapy is better at controlling a specific, aggressive type of uterine cancer (HER2-positive). It will involve 360 patients who have recently been diagnosed and hav…

This study compares two types of radiation therapy—proton therapy and standard IMRT—given after surgery for endometrial or cervical cancer. The goal is to see which one causes fewer bowel and bladder side effects. About 120 people who have had a hysterectomy for these cancers wil…

This study tests whether a personalized activity program using a Fitbit can help people with ovarian or endometrial cancer exercise more and improve their quality of life. About 120 participants will either get the program or standard advice. The goal is to see if the program hel…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study at Mayo Clinic tests new AI image-processing methods (AirRecon DL and Sonic DL) to see if they can make MRI scans faster and clearer for detecting pelvic abnormalities like prostate or endometrial issues. About 60 adults will get standard and AI-enhanced scans, which r…

This study aims to learn why high-risk endometrial cancer comes back by analyzing genetic information from tumor tissue and blood samples. Researchers will follow 100 adults undergoing complete surgical staging at Mayo Clinic to track recurrence-free survival and identify genetic…